Ocular toxicity after inadvertent overdose of intracameral cefuroxime during cataract surgery
| Autor: | Laura Díez-Álvarez, T. Salvá-Palomeque, L Jaumandreu, Gema Rebolleda, M Gómez-Mariscal, Francisco J. Muñoz-Negrete |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
genetic structures medicine.medical_treatment Cataract Optic neuropathy Endophthalmitis Ophthalmology Toxic Optic Neuropathy medicine Humans Retrospective Studies Cefuroxime business.industry Incidence (epidemiology) CORNEAL OEDEMA Retrospective cohort study General Medicine Cataract surgery medicine.disease eye diseases Ocular toxicity Anti-Bacterial Agents sense organs business medicine.drug |
| Zdroj: | Archivos de la Sociedad Espanola de Oftalmologia. 96(11) |
| ISSN: | 2173-5794 |
| Popis: | Purpose To describe intracameral toxic effects of cefuroxime at a higher dose than recommended in cataract surgery. Methods Retrospective study of 8 eyes of 8 patients who inadvertently received 12.5 mg/0.1 ml of intracameral cefuroxime due to a dilution error, at the end of the cataract surgery. All patients underwent a strict ophthalmology follow-up for 6 months. Results All patients presented with a marked anterior segment inflammation with corneal oedema that resolved completely in all cases (between 5 days and 3 months). At 6 months of follow-up a statistically significant difference was found in the corneal endothelial cell density when compared with the fellow eye (P = .038), being Conclusions Although 1 mg/0.1 ml of intracameral cefuroxime has been shown to reduce the incidence of endophthalmitis, its overdose can have potentially toxic eye effects in both anterior and posterior segments. |
| Databáze: | OpenAIRE |
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