Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers
| Autor: | Keun Yong Eom, So Yeon Park, Jae Sung Kim, Changhoon Song, In Ah Kim, Jee Hyun Kim, Sung Won Kim |
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| Jazyk: | angličtina |
| Předmět: |
MAPK/ERK pathway
Adult Breast Neoplasms Kaplan-Meier Estimate chemistry.chemical_compound Phosphatidylinositol 3-Kinases Breast cancer Predictive Value of Tests Heat shock protein Research article medicine Biomarkers Tumor PTEN Humans Neoplasm Invasiveness Phosphatidylinositol HSP90 Heat-Shock Proteins Protein kinase A skin and connective tissue diseases PI3K/AKT/mTOR pathway Medicine(all) biology Kinase PTEN Phosphohydrolase medicine.disease Prognosis Immunohistochemistry chemistry biology.protein Cancer research Female |
| Zdroj: | Breast Cancer Research : BCR |
| ISSN: | 1465-542X |
| DOI: | 10.1186/bcr2557 |
| Popis: | Introduction Evaluating the expression of signaling molecule proteins from the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol-3-kinase (PI3K) pathway in invasive breast cancers may identify prognostic marker(s) associated with early relapse. Methods Immunohistochemical analyses of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), PI3K-p110α, phospho-AKT, phospho-p70S6 kinase, phospho-S6 ribosomal protein, phospho-RAF, phospho-p44/42 MAPK, and heat-shock protein 90 (HSP90) were performed on tumor samples from 212 patients with invasive breast cancer. Statistically significant relations between protein expression, clinicopathologic factors, and relapse-free survival (RFS) were analyzed. Results Expression of HSP90 was associated with 5-year RFS, as well as T stage, N stage, histologic grade, estrogen receptor (ER) expression, human epidermal growth factor receptor 2 (HER2) expression, and the Ki-67 proliferation index. On multivariate analysis, coexpression of HSP90 and PI3K-p110α or expression of HSP90 along with PTEN loss demonstrated significantly worse RFS. In subgroup analyses, both exhibited strong prognostic significance in HER2-positive cases, but not in HER2-negative cases. Conclusions The coexpression of HSP90 with PI3K-p110α or expression of HSP90 along with PTEN loss has a potential as a molecular prognostic marker to predict early relapse in patients with invasive breast cancers. |
| Databáze: | OpenAIRE |
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