Alterations in lipid profile of autistic boys: a case control study
| Autor: | Cheung Soo Shin, Eun-Kyung Kim, Eunkyeong Kim, Eun Mi Kim, Yasmin H. Neggers |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Blood lipids chemistry.chemical_compound Endocrinology High-density lipoprotein Internal medicine Republic of Korea medicine Humans Autistic Disorder Child Triglycerides Dyslipidemias Nutrition and Dietetics Triglyceride medicine.diagnostic_test Cholesterol Cholesterol HDL Cholesterol LDL medicine.disease Lipids chemistry Case-Control Studies Low-density lipoprotein Regression Analysis Autism lipids (amino acids peptides and proteins) Lipid profile Biomarkers Dyslipidemia |
| Zdroj: | Nutrition Research. 30:255-260 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2010.04.002 |
| Popis: | We hypothesize that autism is associated with alterations in the plasma lipid profile and that some lipid fractions in autistic boys may be significantly different than those of healthy boys. A matched case control study was conducted with 29 autistic boys (mean age, 10.1 +/- 1.3 years) recruited from a school for disabled children and 29 comparable healthy boys from a neighboring elementary school in South Korea. Fasting plasma total cholesterol (T-Chol), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), the LDL/HDL ratio, and 1-day food intakes were measured. Multiple regression analyses were performed to assess the association between autism and various lipid fractions. The mean TG level (102.4 +/- 52.4 vs 70.6 +/- 36.3; P = .01) was significantly higher, whereas the mean HDL-C level (48.8 +/- 11.9 vs 60.5 +/- 10.9 mg/dL; P = .003) was significantly lower in cases as compared to controls. There was no significant difference in T-Chol and LDL-C levels between cases and controls. The LDL/HDL ratio was significantly higher in cases as compared to controls. Multiple regression analyses indicated that autism was significantly associated with plasma TG (beta = 31.7 +/- 11.9; P = .01), HDL (beta = -11.6 +/- 2.1; P = .0003), and the LDL/HDL ratio (beta = 0.40 +/- 0.18; P = .04). There was a significant interaction between autism and TG level in relation to plasma HDL level (P = .02). Fifty-three percent of variation in the plasma HDL was explained by autism, plasma TG, LDL/HDL ratio, and the interaction between autism and plasma TG level. These results indicate the presence of dyslipidemia in boys with autism and suggest a possibility that dyslipidemia might be a marker of association between lipid metabolism and autism. |
| Databáze: | OpenAIRE |
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