Efficacy of Oral Cytarabine Ocfosfate and Etoposide in the Treatment of Elderly Patients with Higher-Risk Myelodysplastic Syndromes Compared to That in Elderly Acute Myeloid Leukemia Patients
| Autor: | Yoshihiro Hatta, Jin Takeuchi, Yukio Hirabayashi, Noriyoshi Iriyama, Sumiko Kobayashi, Yoshihito Uchino, Yoshihiro Matsukawa, Katsuhiro Miura, Akira Horikoshi, Hitomi Kodaira, Hiromichi Takahashi |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Oncology medicine.medical_specialty Disease free survival Myeloid Treatment outcome Administration Oral Kaplan-Meier Estimate Disease-Free Survival hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols Drug Discovery Cytidine Monophosphate medicine Humans Pharmacology (medical) Etoposide Aged Aged 80 and over Pharmacology Arabinonucleotides business.industry Myelodysplastic syndromes Myeloid leukemia General Medicine medicine.disease Cytarabine ocfosfate Leukemia Myeloid Acute Leukemia Treatment Outcome Infectious Diseases medicine.anatomical_structure Myelodysplastic Syndromes Female business medicine.drug |
| Zdroj: | Chemotherapy. 59:152-158 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000351114 |
| Popis: | Background: Elderly acute myeloid leukemia (AML) patients and patients with higher-risk myelodysplastic syndromes (MDS) have a much poorer prognosis than younger patients despite intensive chemotherapy. Methods: Ten patients with higher-risk MDS and 12 patients with AML over 65 years of age were enrolled into this study and received oral induction therapy with cytarabine ocfosfate and etoposide. Results: The therapy response rates were 60% in the MDS group and 41.7% in the AML group. The difference in overall survival among MDS and AML patients was not statistically significant. The difference in the median survival times of the responsive and nonresponsive groups, which included MDS and AML patients, was statistically significant (790 and 174 days, respectively). Conclusions: Based on a comparison of the data of this therapy in elderly higher-risk MDS patients versus elderly AML patients, we conclude that this therapy is well tolerated and can be cost-effective and useful for higher-risk MDS in elderly patients. |
| Databáze: | OpenAIRE |
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