Common polymorphisms of calpain-10 are associated with abdominal obesity in subjects at high risk of type 2 diabetes
| Autor: | Jussi Pihlajamäki, Nancy J. Cox, I. Vauhkonen, Markku Vänttinen, Maggie C.Y. Ng, Johanna Kuusisto, Markku Laakso, Eija Ruotsalainen, Urpu Salmenniemi, Graeme I. Bell, Sakari Kainulainen |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Offspring Endocrinology Diabetes and Metabolism medicine.medical_treatment Abdominal Fat Single-nucleotide polymorphism Type 2 diabetes Biology Polymorphism Single Nucleotide Linkage Disequilibrium Insulin resistance Internal medicine Diabetes mellitus Internal Medicine medicine Humans Genetic Predisposition to Disease Obesity Abdominal obesity Pancreatic hormone Finland Aged Calpain Insulin Glucose Tolerance Test Middle Aged medicine.disease Endocrinology Diabetes Mellitus Type 2 Female medicine.symptom |
| Zdroj: | Diabetologia. 49(7) |
| ISSN: | 0012-186X |
| Popis: | The mechanisms by which the calpain-10 gene (CAPN10) affects the risk of type 2 diabetes are unclear. Therefore, we investigated the effects of four polymorphisms in CAPN10 (single nucleotide polymorphism [SNP]-43, SNP-44, Insertion/Deletion [Indel]-19 and SNP-63) on insulin secretion, insulin action and abdominal fat distribution in offspring of patients with type 2 diabetes.Insulin secretion was determined by an IVGTT, insulin action by the hyperinsulinaemic-euglycaemic clamp and abdominal fat distribution by computed tomography in 158 non-diabetic offspring (age 34.9+/-6.3 years [mean+/-SD], BMI 26.2+/-4.9 kg/m(2)) of type 2 diabetic patients.SNP-43 (p=0.009 over the three genotypes, adjusted for age, sex, BMI and family relationship) and haplotypes carrying the A allele of SNP-43 were associated with intra-abdominal fat area. The A allele of SNP-43 was associated with intra-abdominal fat area in men (p=0.014) but not in women. SNP-44, InDel-19 and SNP-63 were not associated with intra-abdominal fat area or insulin action. Furthermore, we demonstrated in a separate sample of middle-aged men (n=234) who had a history of type 2 diabetes in first-degree relatives that the A allele of SNP-43 was associated with a large waist circumference, and high insulin levels in an OGTT.SNP-43 of CAPN10 may contribute to the risk of diabetes by regulating abdominal obesity in subjects with high risk of type 2 diabetes. |
| Databáze: | OpenAIRE |
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