Negative symptoms and longitudinal grey matter tissue loss in adolescents at risk of psychosis: Preliminary findings from a 6-year follow-up study
| Autor: | Andrew C. Stanfield, Stephen M. Lawrie, David G. C. Owens, Heather C. Whalley, T.W. Moorhead, Eve C. Johnstone, Andrew McKechanie |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Pediatrics Adolescent Left posterior Grey matter Young Adult 03 medical and health sciences 0302 clinical medicine Cerebellum medicine Humans Gray Matter Young adult Psychiatry Biological Psychiatry Cerebral Cortex medicine.diagnostic_test Follow up studies Magnetic resonance imaging Sulcus medicine.disease Magnetic Resonance Imaging Temporal Lobe 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Psychotic Disorders Schizophrenia Disease Progression Female Psychology 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | McKechanie, A, Moorhead, T W J, Stanfield, A C, Whalley, H C, Johnstone, E, Lawrie, S M & Owens, D G C 2016, ' Negative symptoms and longitudinal gray matter tissue loss in adolescents at risk of psychosis : Preliminary findings from a 6-year follow-up study. ', British Journal of Psychiatry, vol. 208, no. 6, pp. 565-570 . https://doi.org/10.1192/bjp.bp.114.154526 |
| ISSN: | 1472-1465 0007-1250 |
| DOI: | 10.1192/bjp.bp.114.154526 |
| Popis: | BackgroundNegative symptoms are perhaps the most disabling feature of schizophrenia. Their pathogenesis remains poorly understood and it has been difficult to assess their development over time with imaging techniques.AimsTo examine, using tensor-based structural imaging techniques, whether there are regions of progressive grey matter volume change associated with the development of negative symptoms.MethodA total of 43 adolescents at risk of psychosis were examined using magnetic resonance imaging and whole brain tensor-based morphometry at two time points, 6 years apart.ResultsWhen comparing the individuals with significant negative symptoms with the remaining participants, we identified five regions of significant grey matter tissue loss over the 6-year period. These regions included the left temporal lobe, the left cerebellum, the left posterior cingulate and the left inferior parietal sulcus.ConclusionsNegative symptoms are associated with longitudinal grey matter tissue loss. The regions identified include areas associated with psychotic symptoms more generally but also include regions uniquely associated with negative symptoms. |
| Databáze: | OpenAIRE |
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