The effects of viscero-somatic interactions on thalamic mast cell recruitment in cystitic rats

Autor: Jacques Serviere, David Dubayle, D. Menétrey
Přispěvatelé: Neurophysique et physiologie du système moteur (NPSM), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Centre de neurophysique, physiologie, pathologie (UMR 8119), Modélisation Systémique Appliquée aux Ruminants (MoSAR), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Descartes - Paris 5 (UPD5) - Centre National de la Recherche Scientifique (CNRS), ProdInra, Archive Ouverte, Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Physiologie de la Nutrition et Alimentation (PNA), Institut National de la Recherche Agronomique (INRA) - AgroParisTech
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Male
VISCERA
Visceral Afferents
Stimulation
Functional Laterality
Rats
Sprague-Dawley
0302 clinical medicine
CYCLOPHOSPHAMIDE
Immunology and Allergy
Autonomic Pathways
0303 health sciences
REFERRED PAIN
Solitary tract
Brain
Nociceptors
Anatomy
Chemotaxis
Leukocyte
medicine.anatomical_structure
Neurology
Blood-Brain Barrier
[SDV.IMM]Life Sciences [q-bio]/Immunology
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
medicine.symptom
Proto-Oncogene Proteins c-fos
Immunosuppressive Agents
Spinothalamic tract
[SDV.IMM] Life Sciences [q-bio]/Immunology
Immunology
Thalamus
Pain
Sensory system
Biology
Protective Agents
03 medical and health sciences
medicine
Animals
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Mesna
030304 developmental biology
Afferent Pathways
MAST CELLS
Hyperesthesia
Visceral pain
Rats
Olfactory bulb
Disease Models
Animal
RAT
Neurology (clinical)
CYSTITIS
030217 neurology & neurosurgery
THALAMUS
Zdroj: Journal of Neuroimmunology
Journal of Neuroimmunology, Elsevier, 2007, epub ahead of print. ⟨10.1016/j.jneuroim.2007.07.012⟩
Journal of Neuroimmunology, Elsevier, 2007, 190 (1-2), pp.18-27
Journal of Neuroimmunology, Elsevier, 2007, epub ahead of print. 〈10.1016/j.jneuroim.2007.07.012〉
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2007.07.012⟩
Popis: Mast cells accessing the brain parenchyma through the blood-brain barrier in healthy animals are limited to pre-cortical sensory relays - the olfactory bulb and the thalamus. We have demonstrated that unilateral repetitive stimulation of the abdominal wall generates asymmetry in midline thalamic mast cell (TMC) distribution in cyclophosphamide-injected rats, consisting of contralateral side-prevalence with respect to the abdominal wall stimulation. TMC asymmetry 1) was generated in strict relation with cystitis, and was absent in disease-free and mesna-treated animals, 2) was restricted to the anterior portion of the paraventricular pars anterior and reuniens nuclei subregion, i.e., the rostralmost part of the paraventricular thalamic nucleus, the only thalamic area associated with viscero-vagal and somatic inputs, via the nucleus of the solitary tract, and via the medial contingent of the spinothalamic tract, respectively, and 3) originated from somatic tissues, i.e., the abdominal wall where bladder inflammation generates secondary somatic hyperesthesia leading to referred pain in humans. Present data suggest that TMCs may be involved in thalamic sensory processes, including some aspects of visceral pain and abnormal visceral/somatic interactions.
Databáze: OpenAIRE
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