How to use bleomycin A5 for infantile maxillofacial haemangiomas: Clinical evaluation of 82 consecutive cases
| Autor: | Fuyun Zhao, Quan-Feng Luo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Lidocaine Injections Intralesional Bleomycin Lesion chemistry.chemical_compound Infantile haemangioma Neoplastic Syndromes Hereditary Prednisone medicine Humans Hemangioma Capillary Stage (cooking) Glucocorticoids Dexamethasone Antibiotics Antineoplastic business.industry Infant Sclerosing Solutions Surgery Treatment Outcome Otorhinolaryngology chemistry Anesthesia Drug Therapy Combination Female Facial Neoplasms Oral Surgery medicine.symptom business Clinical evaluation medicine.drug |
| Zdroj: | Journal of Cranio-Maxillofacial Surgery. 39:482-486 |
| ISSN: | 1010-5182 |
| DOI: | 10.1016/j.jcms.2010.06.002 |
| Popis: | Objective Bleomycin A5 has been reported effective for infantile haemangioma (IH), but the usage and complications were described a little. We have used bleomycin A5 to treat maxillofacial IHs for 15 years. This paper describes the procedures to use bleomycin A5 and avoid its complications based on our clinical practices. Methods Bleomycin A5 (8 mg, powder) was mixed with 2% lidocaine (3 ml) and dexamethasone (1 ml, 5 mg), the mixture concentration is 2 mg/ml (bleomycin A5). The drug was given by multiple intralesional injections, with the dosage calculated according to the age of the patient and size of the lesion. Cautions were paid to the drug dosage and concentration, as well as the depth of injection. The patients were also given oral prednisone (2–5 mg/kg every other day) during proliferating stage. Results After treatment with bleomycin A5 in appropriate quantity and concentration, injecting depth, all haemangiomas involuted completely, with smaller lesions showing better recovery of skin colour and less scar formation, and no serious side effects happened. Conclusion Bleomycin A5 is an effective treatment for IHs. Oral prednisone is necessary for patients at proliferating stage. |
| Databáze: | OpenAIRE |
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