Neurological manifestations due to dengue virus infection in children: clinical follow-up
| Autor: | Erna Geessien Kroon, Luciana Maria Silva, Alice Martins Alvarenga, Ana Paula Correa Crispim, Isabela Guedes, Karina Soares Loutfi, Paula Eillanny Silva Marinho, Aline Almeida Bentes, Marcele Almeida Santos, Sara Tavares Araujo, Roberta Maia de Castro Romanelli |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Ataxia Dengue virus medicine.disease_cause Microbiology Dengue fever Dengue medicine Humans Prospective Studies Prospective cohort study Child Paresis business.industry Public Health Environmental and Occupational Health General Medicine Dengue Virus medicine.disease Infectious Diseases Immunoglobulin M Etiology Parasitology medicine.symptom Headaches business Meningitis Follow-Up Studies Research Article |
| Zdroj: | Pathog Glob Health |
| ISSN: | 2047-7732 |
| Popis: | The aim was to assess neurological complications in children with an invasive neurological disease by dengue virus (DENV) and the time to resolve symptoms after hospital discharge. A prospective study was conducted at a referral hospital for infectious diseases in Brazil between March 2014 and July 2019. All children hospitalized with neurologic manifestations and DENV RNA detected by real-time reverse transcription-polymerase chain reaction (RT-qPCR) in cerebrospinal fluid (CSF) were followed up until complete resolution of neurological complications. On average, they were followed up for 16 months. Among 56 DENV-positive children, 39% had some neurologic complications after hospital discharge and found that 19.6% were discharged with anticonvulsants due to seizures, 10.7% developed motor complications (e.g. muscle weakness, paresis, ataxia, and walking disability), 5.4% had headaches, and 14.3% had sleep disorders. Among the 56 children, only three had a clinical diagnosis of dengue because the symptoms are nonspecific and 35% showed no change in cerebrospinal fluid (CSF). The average time to resolve complications was 5.9 months (ranging from 1 m to 32 m). These results should alert physicians to the difficulties of a clinical diagnosis of an infection that causes neurological complications after discharge in a significant number of children. RT-qPCR's etiological diagnosis of DENV infection enabled better clinical follow-up for early intervention in children with neurological complications. |
| Databáze: | OpenAIRE |
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