Data analysis for dynamic contrast-enhanced MRI-based cerebral perfusion measurements: correcting for changing cortical CSF volumes
| Autor: | Richard J. Haier, J. F. Emerson, P C Chen, W. R. Shankle, Orhan Nalcioglu |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Biophysics Partial volume Blood volume Cerebrospinal fluid Reference Values medicine Humans Radiology Nuclear Medicine and imaging Cerebral perfusion pressure Vascular dementia Aged Cerebrospinal Fluid Aged 80 and over Cerebral Cortex Blood Volume Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Cerebral blood flow Cerebrovascular Circulation Data Interpretation Statistical Dynamic contrast-enhanced MRI Dementia Radiology business Nuclear medicine |
| Zdroj: | Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine. 3:41-48 |
| ISSN: | 1352-8661 |
| DOI: | 10.1007/bf02426399 |
| Popis: | The time evolution of the histogram (number of pixels versus signal intensity) is used to calculate delta R2 parameters from dynamic contrast-enhanced magnetic resonance (MR) imaging of the brain. This method partially corrects for partial volume effects and is an improvement over the approach using the signal intensity as a function of time when confounding factors such as changing cortical cerebrospinal fluid volumes are involved. The maximum value for delta R2 is found to correlate with relative cerebral blood flow as assessed by xenon inhalation and can be used to discriminate between vascular dementia and healthy volunteers. With this method, the normal range for delta R2 values is found to be the same for both young (19-40 years old) and elderly (65-85 years old) healthy volunteers. |
| Databáze: | OpenAIRE |
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