Predictors for Late Post-Intracerebral Hemorrhage Dementia in Patients with Probable Cerebral Amyloid Angiopathy
| Autor: | Emily Benson, Steven M. Greenberg, Gregoire Boulouis, Thanakit Pongpitakmetha, Li Xiong, Edip M Gurol, Sanjula D. Singh, Anand Viswanathan, Jonathan Rosand, Alessandro Biffi, Markus D. Schirmer, Andreas Charidimou, Marco Pasi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male psychology [Cerebral Amyloid Angiopathy] psychology [Cerebral Hemorrhage] Cohort Studies 0302 clinical medicine methods [Magnetic Resonance Imaging] diagnostic imaging [Dementia] Prospective Studies Prospective cohort study Aged 80 and over General Neuroscience General Medicine Magnetic Resonance Imaging Superficial siderosis diagnostic imaging [Cerebral Amyloid Angiopathy] Psychiatry and Mental health Clinical Psychology Female Cerebral amyloid angiopathy medicine.medical_specialty psychology [Dementia] trends [Magnetic Resonance Imaging] Article 03 medical and health sciences Predictive Value of Tests Internal medicine mental disorders medicine Dementia Humans cardiovascular diseases ddc:610 Cerebral Hemorrhage Aged Intracerebral hemorrhage Past medical history Proportional hazards model business.industry diagnostic imaging [Cerebral Hemorrhage] medicine.disease Hyperintensity nervous system diseases Cerebral Amyloid Angiopathy 030104 developmental biology Geriatrics and Gerontology business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Alzheimer's disease 71(2), 435-442 (2019). doi:10.3233/JAD-190346 J Alzheimers Dis |
| DOI: | 10.3233/JAD-190346 |
| Popis: | Background and objective Cerebral amyloid angiopathy (CAA) accounts for the majority of lobar intracerebral hemorrhage (ICH); however, the risk factors for dementia conversion after ICH occurrence in CAA patients are unknown, especially in the long-term period after ICH. Therefore, we aimed to unravel the predictors for late post-ICH dementia (6 months after ICH event) in probable CAA patients. Methods From a large consecutive MRI prospective cohort of spontaneous ICH (2006-2017), we identified probable CAA patients (modified Boston criteria) without dementia 6 months post-ICH. Cognitive outcome during follow-up was determined based on the information from standardized clinical visit notes. We used Cox regression analysis to investigate the association between baseline demographic characteristics, past medical history, MRI biomarkers, and late post-ICH dementia conversion (dementia occurred after 6 months). Results Among 97 non-demented lobar ICH patients with probable CAA, 25 patients (25.8%) developed dementia during a median follow-up time of 2.5 years (IQR 1.5-3.8 years). Pre-existing mild cognitive impairment, increased white matter hyperintensities (WMH) burden, the presence of disseminated cortical superficial siderosis (cSS), and higher total small vessel disease score for CAA were all independent predictors for late dementia conversion. Conclusion In probable CAA patients presenting with lobar ICH, high WMH burden and presence of disseminated cSS are useful neuroimaging biomarkers for dementia risk stratification. These findings have implications for clinical practice and future trial design. |
| Databáze: | OpenAIRE |
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