Organ at risk dose comparison between gynaecological cancers of the endometrium and cervix using a combined external beam and brachytherapy boost treatment
| Autor: | Rachel Hanley, Anysja Zuchora |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Dose comparison medicine.medical_treatment Brachytherapy Biophysics Urology General Physics and Astronomy General Medicine Endometrium medicine.anatomical_structure Quality of life Organ at risk medicine Photon beams Radiology Nuclear Medicine and imaging External beam radiotherapy business Cervix |
| Zdroj: | Physica Medica. 52:167 |
| ISSN: | 1120-1797 |
| DOI: | 10.1016/j.ejmp.2018.06.022 |
| Popis: | Gynaecological cancers (GCs) treated using external beam radiotherapy (EBRT) followed by a boost of brachytherapy (BT) reduces the overall treatment dose and gives a better treatment of the tumour compared to using EBRT or BT alone. However, with this combined treatment, there is growing concern for the increased dose to the Organs at Risk (OAR) as it increases the possibility of late toxicity effects and potentially reduces the patient’s quality of life (QoL). Using statistical analysis, the differences in dose delivered to the OAR for two GCs (endometrial and cervical) was investigated as well as other dose influencing factors (i.e. applicator insertion angle and size). This project involved 19 cervical patients: EBRT = 50.4 Gy, 28 fractions followed by BT = 21 Gy, 3 fractions; and 17 endometrial patients: EBRT = 45/46 Gy, 28 fractions and BT = 18 Gy 3 fractions. All patients had been treated with 3D-Conformal EBRT using 15 MV photon beams and BT with a Ir-192 GammaMed Plus system. Statistically significant differences (p-value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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