Development of Chiral Catalysts by Asymmetric Activation for Highly Enantioselective Diethylzinc Addition to Imines

Autor:	Yaozhong Jiang, Hai-Le Zhang, Aiqiao Mi, Hua Liu, Xin Cui, Liu-Zhu Gong
Rok vydání:	2005
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Imine Enantioselective synthesis chemistry.chemical_element Organic chemistry General Medicine Zinc Diethylzinc Combinatorial chemistry Catalysis
Zdroj:	ChemInform. 36
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200532088
Popis:	Based on the asymmetric activation concept, a library of chiral zinc complexes in situ formed by the combination of diimines derived from chiral 1,2-diphenyl-ethanene-1,2-diamine, BINOL derivatives, and diethylzinc are evaluated in the asymmetric addition of diethylzinc to N-acylimines. In the presence of 10 mol% L3ZnAl, high enantioselectivities and yields were provided for a wide range of aromatic imines in 1,2-dichloroethane at -25 °C.
Databáze:	OpenAIRE
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