ALS is a multistep process in South Korean, Japanese, and Australian patients
| Autor: | Eun Mi Kim, Yuriko Doi, Steve Vucic, Parvathi Menon, Ki-Wook Oh, Inah Kim, Mana Higashihara, Matthew C. Kiernan, Satoshi Kuwabara, Naoki Atsuta, Seung Hyun Kim, Jin-Seok Park, Gen Sobue, Paul Talman |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Population Age and sex Article 03 medical and health sciences 0302 clinical medicine Japan Republic of Korea Humans Medicine education Aged education.field_of_study business.industry Incidence Mortality rate Incidence (epidemiology) Amyotrophic Lateral Sclerosis Racial Groups Disease progression Australia Middle Aged Confidence interval 030104 developmental biology Linear relationship Disease Progression Linear relation Female Neurology (clinical) business 030217 neurology & neurosurgery Demography |
| Zdroj: | Neurology |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0000000000009015 |
| Popis: | ObjectiveTo establish whether amyotrophic lateral sclerosis (ALS) is a multistep process in South Korean and Japanese populations when compared to Australian cohorts.MethodsWe generated incident data by age and sex for Japanese (collected between April 2009 and March 2010) and South Korean patients with ALS (collected between January 2011 and December 2015). Mortality rates were provided for Australian patients with ALS (collected between 2007 and 2016). We regressed the log of age-specific incidence against the log of age with least squares regression for each ALS population.ResultsWe identified 11,834 cases of ALS from the 3 populations, including 6,524 Australian, 2,264 Japanese, and 3,049 South Korean ALS cases. We established a linear relation between the log incidence and log age in the 3 populations: Australia r2 = 0.99, Japan r2 = 0.99, South Korea r2 = 0.99. The estimate slopes were similar across the 3 populations, being 5.4 (95% confidence interval [CI], 4.8–5.5) in Japanese, 5.4 (95% CI, 5.2–5.7) in Australian, and 4.4 (95% CI, 4.2–4.8) in South Korean patients.ConclusionsThe linear relationship between log age and log incidence is consistent with a multistage model of disease, with slope estimated suggesting that 6 steps were required in Japanese and Australian patients with ALS while 5 steps were needed in South Korean patients. Identification of these steps could identify novel therapeutic strategies. |
| Databáze: | OpenAIRE |
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