Injectable tricalcium phosphate/calcium sulfate granule enhances bone repair by reversible setting reaction
| Autor: | Chang Han, Kai-Yuan Cheng, Wei Zhu, Yang Liu, Wei Xia, Xisheng Weng, Lin-Jie Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Calcium Phosphates
Male 0301 basic medicine Scaffold Bone Regeneration Biophysics chemistry.chemical_element Bone healing Calcium Calcium Sulfate Biochemistry 03 medical and health sciences 0302 clinical medicine X-Ray Diffraction Downregulation and upregulation Osteogenesis Animals Humans Molecular Biology Osteoblasts Tissue Engineering Tissue Scaffolds Mesenchymal stem cell Granule (cell biology) Bone Cements Mesenchymal Stem Cells Cell migration Cell Biology Porous scaffold 030104 developmental biology chemistry 030220 oncology & carcinogenesis Microscopy Electron Scanning Rabbits Porosity Biomedical engineering |
| Zdroj: | Biochemical and Biophysical Research Communications. 557:151-158 |
| ISSN: | 0006-291X |
| Popis: | Towards repairing bone defects, calcium sulfate and calcium phosphate cement have been recognized as promising bone grafts. However, the current bone cements are generally lack of proper porosity for cell migration and new tissue formation. On the other hand, porous scaffold cannot be delivered by injection, which limits its use its clinical use. Herein, we develop a novel tricalcium phosphate/calcium sulfate granule to overcome the limitations of injectable cements and traditional scaffolds. The biocompatible granule underwent in situ self-setting to form scaffold with porous structure after injection. It contributes to calcium deposition and upregulation of osteogenic genes of mesenchymal stem cells in a time-dependent manner. Within three months, cavitary bone defects of distal rabbit femurs implanted the granules exhibited better bone formation than those with those implanted with autologous bone. |
| Databáze: | OpenAIRE |
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