Oncogenic nature of a novel mutant AATF and its interactome existing within human cancer cells
| Autor: | Deepti Malik, Shaveta Sharma, Mansi Arora, Deepak Kaul |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Sp1 Transcription Factor
DNMT3B Mutant Molecular Sequence Data Down-Regulation Biology Oncogenomics Interactome law.invention Transcriptome Jurkat Cells law Cell Line Tumor Neoplasms Autophagy Humans Amino Acid Sequence DNA (Cytosine-5-)-Methyltransferases RNA Small Interfering Promoter Regions Genetic Cell Biology General Medicine DNA Methylation G1 Phase Cell Cycle Checkpoints Cell biology Repressor Proteins DNA methylation Cancer cell Mutation Suppressor RNA Interference Apoptosis Regulatory Proteins HeLa Cells |
| Zdroj: | Cell biology international. 39(3) |
| ISSN: | 1095-8355 |
| Popis: | Since apoptosis presents a natural defense in cancer development, the anti-apoptotic factor AATF/Che-1 has emerged as a crucial ‘Epigenomic-Switch’. We have tried to understand the double-edged nature of AATF, showing for the first time the conspicuous existence of an aberrant AATF/Che-1 transcriptome encoding for 23 kDa mutant AATF protein, which evolves its unique interactome within human cancer cells derived from different tissue origins. This mutant AATF along with its interactome consisting of SP1, DNMT3B and Par-4 ensures cancer cell DNA methylation required for down-regulation of tumor suppressor genes. Hence, the proposed mutant AATF interactome-based pathway can have the inherent ability to ensure human cells become and remain cancerous. |
| Databáze: | OpenAIRE |
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