Osteoarthrosis induced by intra-articular hydrogen peroxide injection and running load
| Autor: | Akimi Sano, Norikazu Hirano, Takanobu Yonezawa, Genkyo Kaiki, Shinichiro Yamashita, Takashi Takano, Haruo Tsuji, Hiromichi Sekido |
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| Rok vydání: | 1990 |
| Předmět: |
Vitamin
Male medicine.medical_specialty medicine.medical_treatment Osteoarthritis Knee Joint Sodium Chloride Injections Intra-Articular Running chemistry.chemical_compound Intra articular medicine Animals Vitamin E Orthopedics and Sports Medicine Regular diet Hydrogen peroxide Inhibitory effect business.industry Osmolar Concentration Rats Inbred Strains Hydrogen Peroxide medicine.disease Surgery Diet Rats Radiography chemistry Anesthesia business |
| Zdroj: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 8(5) |
| ISSN: | 0736-0266 |
| Popis: | Osteoarthrosis of the rat knee joint was induced successfully by intra-articular injection of 2% hydrogen peroxide (H2O2) and running load. In the group receiving two injections of physiological saline with running load, no histological osteoarthrotic knees were developed up to 8 weeks after the injection. In the group receiving two 2% H2O2 injections and running load, advanced osteoarthrosis occurred in all knees 8 weeks after the first injection, and the Mankin's score of osteoarthrotic knees appeared to be higher than the group receiving two 2% H2O2 injections without running load (p less than 0.004, Kruskal-Wallis H test). In the rats receiving a single 2% H2O2 injection with running load and a vitamin E-enriched diet, the inhibitory effect of vitamin E on the development of osteoarthrosis was statistically significant compared to the regular diet group (p less than 0.05, Wilcoxon rank test). |
| Databáze: | OpenAIRE |
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