Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research
| Autor: | Batu K. Sharma-Kuinkel, Pratik Shah, Nicholas A Turner, Stacey A. Maskarinec, Vance G. Fowler, Emily M. Eichenberger, Thomas L. Holland, Manuela Carugati |
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| Rok vydání: | 2019 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty Bacteremia Biology medicine.disease_cause Microbiology Article Evolution Molecular Methicillin 03 medical and health sciences High morbidity Epidemiology medicine Humans Endocarditis Intensive care medicine Clinical Trials as Topic Cross Infection 0303 health sciences General Immunology and Microbiology 030306 microbiology Incidence Soft Tissue Infections Genetic Variation Staphylococcal Infections bacterial infections and mycoses Antimicrobial medicine.disease Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents Community-Acquired Infections Infectious Diseases Clinical research Infectious disease (medical specialty) Staphylococcus aureus |
| Zdroj: | Nature Reviews Microbiology. 17:203-218 |
| ISSN: | 1740-1534 1740-1526 |
| DOI: | 10.1038/s41579-018-0147-4 |
| Popis: | Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA. |
| Databáze: | OpenAIRE |
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