Effect of moderate obesity on glucose transport in human muscle
| Autor: | Edward B. Tapscott, C W Elton, Pories Wj, Dohm Gl |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Rectus Abdominis Stimulation Biology Deoxyglucose In Vitro Techniques Biochemistry Endocrinology Insulin resistance Insulin-Like Growth Factor II Internal medicine medicine Humans Insulin Obesity Insulin-Like Growth Factor I Muscles Biochemistry (medical) Body Weight Glucose transporter Skeletal muscle Methylglucosides General Medicine medicine.disease medicine.anatomical_structure Glucose 3-O-Methylglucose Female Body mass index Hormone |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 26(4) |
| ISSN: | 0018-5043 |
| Popis: | We have shown that maximally stimulated glucose transport is reduced in in vitro incubated muscle of morbidly obese subjects. To investigate the possibility that a "threshold" of obesity exists, above which glucose transport is significantly decreased, hormone (insulin, IGF-I, or IGF-II) stimulation of glucose transport was correlated with body mass index using muscle biopsies from a group of 30 lean to obese females with BMI ranging from 16 to 40. There was a significant negative relationship between stimulation for glucose transport and BMI (R = 0.765). These data suggest there is no obesity threshold for insulin resistance in skeletal muscle but a continuous decline in glucose transport below a BMI of approximately 30 kg/m2, after which insulin and the IGFs no longer stimulate glucose transport. |
| Databáze: | OpenAIRE |
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