Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 1. 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acids

Autor:	Daniel E. Aultz, Grover C. Helsley, David Hoffman, Arthur R. McFadden, Howard B. Lassman, Jeffrey C. Wilker
Rok vydání:	1977
Předmět:	Nonsteroidal Stereochemistry Arthritis Anti-Inflammatory Agents Drug Evaluation Preclinical Carbonyl group Rats Carrageenan Mice Structure-Activity Relationship chemistry.chemical_compound chemistry Drug Discovery Animals Edema Molecular Medicine Dibenzoxepins Derivative (chemistry) Paw edema
Zdroj:	Journal of Medicinal Chemistry. 20:66-70
ISSN:	1520-4804 0022-2623
DOI:	10.1021/jm00211a013
Popis:	A series of 6,11-dihydrodibenz[b,e]oxepin-2-acetic acids has been evaluated for both antiinflammatory and analgetic activity in the carrageenan paw edema and phenylquinone writhing assays. The requirements for optimal activity in this series appear rather specific: (a) an unsubstituted 6,11-dihydrodibenz[b,e]oxepin nucleus and (b) a carbonyl group in the 11 position. One derivative, 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid (11), has been selected for further study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd43d44f1459ad7b0810ad5d1042f13 https://doi.org/10.1021/jm00211a013 Zobrazit plný text záznamu