Endogenous heparin activity deficiency: the 'missing link' in atherogenesis?
| Autor: | Hyman Engelberg |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Chemokine Arteriosclerosis medicine.medical_treatment Endogeny Inflammation Biology Peptidyl-Dipeptidase A Sensitivity and Specificity Phospholipases A Glycosaminoglycan Risk Factors Internal medicine medicine Animals Humans Lipoprotein lipase Heparin Haplorhini Prognosis carbohydrates (lipids) Lipoprotein Lipase Endocrinology Cytokine Immunology biology.protein medicine.symptom Chemokines Cardiology and Cardiovascular Medicine Lipoprotein medicine.drug |
| Zdroj: | Atherosclerosis. 159(2) |
| ISSN: | 0021-9150 |
| Popis: | This paper reviews published studies since 1995 dealing with many atherogenic mechanisms where exogenous heparin was beneficial. In these areas endogenous heparin deficiency is likely to be harmful. Mechanisms included inflammatory factors, lower endogenous plasma heparin levels, lipoprotein lipase, chemokines, APOE e4, lipoprotein(a), among others. Demonstrated reduction of heparan sulfate proteoglycans (HSPG) and of endogenous plasma heparin was reviewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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