Two cases of Robertsonian translocations in oligozoospermic males and their consequences for pregnancies induced by intracytoplasmic sperm injection
| Autor: | R. F. A. Weber, M.H.E.C. Pieters, Marc Dhont, N den Hollander, Frans J. Los, P A Veld, J. O. Van Hemel |
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| Přispěvatelé: | Clinical Genetics, Internal Medicine, Obstetrics & Gynecology |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cytoplasm medicine.medical_specialty Microinjections medicine.medical_treatment Abnormal Pregnancy Robertsonian translocation Chromosomal translocation Biology medicine.disease_cause Translocation Genetic Intracytoplasmic sperm injection Andrology Pregnancy medicine Humans reproductive and urinary physiology Twin Pregnancy Insemination Artificial Homologous Gynecology Rehabilitation Obstetrics and Gynecology Karyotype Oligospermia medicine.disease Spermatozoa Pregnancy Complications Reproductive Medicine Chromosome abnormality Female |
| Zdroj: | Human Reproduction, 12(8), 1642-1644. Oxford University Press |
| ISSN: | 1460-2350 0268-1161 |
| Popis: | Two case histories are presented documenting structural chromosome abnormalities in infertile males. The abnormalities were detected only after application of intracytoplasmic sperm injection (ICSI) was repeatedly unsuccessful or resulted in an abnormal pregnancy. A mosaic Robertsonian translocation 45,XY,der(13;13)(q10; q10)/46,XY,t(13;13)(p10;p10), der(13p;13p) incompatible with normal offspring was found in a male with extreme oligozoospermia after three subsequent ICSI treatments were unsuccessful and one had resulted in a spontaneous abortion. A second case involved a Robertsonian translocation 45,XY,der(13;14)(q10;q10) which was detected in a male with extreme oligozoospermia after ultrasound abnormalities were found in an ICSI-induced twin pregnancy. Amniocentesis showed an unbalanced 46,XY,+13,der(13;14)(q10;q10) karyotype in one twin and a Robertsonian 45,XX,der(13;14)(q10;q10) karyotype in the other twin. Chromosome analysis of males with abnormal sperm characteristics is advised prior to ICSI. |
| Databáze: | OpenAIRE |
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