Unilateral suppression of P/N13′ potential amplitude in young patients with persistent numbness due to cervical monoradiculopathy. A case-control study
| Autor: | Christos Moschovos, Andreas Kyrozis, Apostolia Ghika |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
animal structures Evoked potential Dermatomal Somatosensory Somatosensory system Asymptomatic lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Physiology (medical) Medicine 030212 general & internal medicine Radiculopathy lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry P/N13′ negative peak at 13 ms business.industry fungi Case-control study Amplitude ratio Surgery DSEP Amplitude Neurology Somatosensory evoked potential Clinical and Research Article DSEP Dermatomal Somatosensory Evoked Potentials Anesthesia embryonic structures Neurology (clinical) medicine.symptom business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery P/N13′ |
| Zdroj: | Clinical Neurophysiology Practice, Vol 2, Iss, Pp 1-7 (2017) Clinical Neurophysiology Practice |
| ISSN: | 2467-981X |
| DOI: | 10.1016/j.cnp.2016.10.002 |
| Popis: | Highlights • DSEPs unilaterally suppressed to ⩽50% in young patients with persistent numbness. • DSEPs not consistently suppressed in young patients with intermittent numbness. • DSEP measurements inconsistent at ages >55 years. Objective The utility of Dermatomal Somatosensory Evoked Potentials (DSEPs) in the diagnostic workup of suspected cervical monoradiculopathy has been limited by significant overlap between measurements obtained from affected versus unaffected roots. In a case-control study, we explored whether, under certain conditions, asymmetry in DSEP parameters may offer significant help in the diagnosis of monoradiculopathy. Methods DSEPs were obtained bilaterally from patients with persistent (age range 33–55, n = 10) or intermittent (age range 31–55, n = 7) unilateral sensory symptoms of less than one month duration due to MRI-confirmed cervical monoradiculopathy. DSEPs were also obtained bilaterally from aged-matched asymptomatic volunteers (age range 31–54, n = 8) and older asymptomatic volunteers (age range 57–77, n = 8). Amplitude and latency of the P/N13′ potential (negative peak at 13 ms) were measured. Results In all ten patients with persistent symptoms, the P/N13′ amplitude ratio, defined as P/N13′ amplitude on the symptomatic side divided by P/N13′ amplitude on the contralateral asymptomatic side, ranged between 0.0 and 0.50 (unilateral suppression). In all seven patients with intermittent symptoms, P/N13′ amplitude ratios ranged between 0.60 and 1.00. In all age-matched asymptomatic controls, P/N13′ amplitude ratio (side with lower divided by side with higher amplitude) was always at least 0.80. Among older asymptomatic subjects, DSEPs had inconsistent characteristics. Conclusions Cervical monoradiculopathy with persistent numbness in young patients (aged up to 55 years) is very strongly associated with unilateral suppression of P/N13′ DSEP amplitude. No significant asymmetry is observed in cases of monoradiculopathy with intermittent numbness. Significance In young patients with unilateral upper extremity persistent sensory complaints, DSEP amplitude asymmetry, as quantified by the P/N13′ ratio, may offer significant help in the diagnosis of monoradiculopathy. |
| Databáze: | OpenAIRE |
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