Partial volume correction in arterial spin labeling perfusion MRI
| Autor: | Flora A. Kennedy McConnell, Matthias J.P. van Osch, Xavier Golay, Juan Antonio Hernández-Tamames, Matthias Günther, Iris Asllani, Michael A. Chappell |
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| Přispěvatelé: | Radiology & Nuclear Medicine, Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pyridines
Arterial spin labeling Partial volume Perfusion scanning computer.software_genre Hippocampus 0302 clinical medicine Voxel Image Processing Computer-Assisted Entorhinal Cortex Carbon Radioisotopes Aging and dementia Aniline Compounds Membrane Glycoproteins 05 social sciences fMRI Brain Organ Size Anatomy Magnetic Resonance Imaging Pyrrolidinones Cerebral Blood Flow Perfusion medicine.anatomical_structure Neurology Cerebral blood flow Partial volume effect Synaptic Vesicles Algorithms RC321-571 MRI Cognitive Neuroscience Nerve Tissue Proteins Neuroimaging Neurosciences. Biological psychiatry. Neuropsychiatry 050105 experimental psychology White matter 03 medical and health sciences Alzheimer Disease medicine Cognitive Dysfunction 0501 psychology and cognitive sciences Amyloid beta-Peptides business.industry Cerebral Arteries Thiazoles Positron-Emission Tomography Spin Labels Radiopharmaceuticals Atrophy business computer 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage, 238:118236. Academic Press NeuroImage, 238. ACADEMIC PRESS INC ELSEVIER SCIENCE NeuroImage, Vol 238, Iss, Pp 118236-(2021) |
| ISSN: | 1053-8119 |
| Popis: | The mismatch in the spatial resolution of Arterial Spin Labeling (ASL) MRI perfusion images and the anatomy of functionally distinct tissues in the brain leads to a partial volume effect (PVE), which in turn confounds the estimation of perfusion into a specific tissue of interest such as gray or white matter. This confound occurs because the image voxels contain a mixture of tissues with disparate perfusion properties, leading to estimated perfusion values that reflect primarily the volume proportions of tissues in the voxel rather than the perfusion of any particular tissue of interest within that volume. It is already recognized that PVE influences studies of brain perfusion, and that its effect might be even more evident in studies where changes in perfusion are co-incident with alterations in brain structure, such as studies involving a comparison between an atrophic patient population vs control subjects, or studies comparing subjects over a wide range of ages. However, the application of PVE correction (PVEc) is currently limited and the employed methodologies remain inconsistent. In this article, we outline the influence of PVE in ASL measurements of perfusion, explain the main principles of PVEc, and provide a critique of the current state of the art for the use of such methods. Furthermore, we examine the current use of PVEc in perfusion studies and whether there is evidence to support its wider adoption. We conclude that there is sound theoretical motivation for the use of PVEc alongside conventional, ‘uncorrected’, images, and encourage such combined reporting. Methods for PVEc are now available within standard neuroimaging toolboxes, which makes our recommendation straightforward to implement. However, there is still more work to be done to establish the value of PVEc as well as the efficacy and robustness of existing PVEc methods. |
| Databáze: | OpenAIRE |
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