Follow-up Creatinine Level Is an Important Predictive Factor of In-hospital Mortality in Cirrhotic Patients with Spontaneous Bacterial Peritonitis
| Autor: | Young Don Kim, Baek Gyu Jun, Soung Won Jeong, Sae Hwan Lee, Young Sin Cho, Jae Young Jang, Sang Gyune Kim, Hong Soo Kim, Young Seok Kim, Gab Jin Cheon, Woong Cheul Lee, Yun Nah Lee |
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| Rok vydání: | 2018 |
| Předmět: |
Liver Cirrhosis
Male 0301 basic medicine medicine.medical_specialty Cirrhosis Renal Function Renal function Peritonitis Spontaneous Bacterial Peritonitis Severity of Illness Index Gastroenterology 03 medical and health sciences Liver disease chemistry.chemical_compound 0302 clinical medicine Spontaneous bacterial peritonitis Risk Factors Internal medicine Escherichia coli medicine Humans Escherichia coli Infections Retrospective Studies Creatinine Gastroenterology & Hepatology business.industry Retrospective cohort study General Medicine Hepatitis C Middle Aged Hepatitis B Prognosis medicine.disease Klebsiella Infections Klebsiella pneumoniae 030104 developmental biology chemistry Original Article Female 030211 gastroenterology & hepatology business Serum Creatinine Level |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| DOI: | 10.3346/jkms.2018.33.e99 |
| Popis: | Background Spontaneous bacterial peritonitis (SBP) is one of the severe complications of liver cirrhosis. Early detection of high-risk patients is essential for prognostic improvement. The aim of this study is to investigate the predictive factors related to in-hospital mortality in patients with SBP. Methods This was a retrospective study of 233 SBP patients (181 males, 52 females) who were admitted to four tertiary referral hospitals between August 2002 and February 2013. The patients' laboratory and radiologic data were obtained from medical records. The Child-Turcotte-Pugh (CTP) score and model for end-stage liver disease sodium model (MELD-Na) scores were calculated using the laboratory data recorded at the time of the SBP episode. Results The causes of liver cirrhosis were hepatitis B (44.6%), alcohol (43.8%), hepatitis C (6.0%), and cryptogenic cirrhosis (5.6%). The mean MELD-Na and CTP scores were 27.1 and 10.7, respectively. Thirty-one of the patients (13.3%) died from SBP in hospital. Multivariate analysis revealed that maximum creatinine level during treatment was a statistically significant factor for in-hospital mortality (P = 0.005). The prognostic accuracy of the maximum creatinine level during treatment was 78.0% (P < 0.001). The optimal cutoff point for the maximum serum creatinine was 2 mg/dL (P < 0.001). Conclusion The follow-up creatinine level during treatment is an important predictive factor of in-hospital mortality in cirrhotic patients with SBP. Patients with SBP and a serum creatinine level during treatment of ≥ 2.0 mg/dL might have a high risk of in-hospital mortality. Graphical Abstract |
| Databáze: | OpenAIRE |
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