Verocytotoxin-producing Escherichia coli infection in household members of children with hemolytic-uremic syndrome in the Netherlands
| Autor: | van de Kar Nc, Van Der Velden Tj, Monnens La, Chart H, Heuvelink Ae |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Diarrhea
Lipopolysaccharides Male Parents Microbiology (medical) Hemolytic anemia medicine.medical_specialty Bacterial Toxins Verocytotoxin Escherichia coli O157 Shiga Toxin 1 chemistry.chemical_compound fluids and secretions Epidemiology medicine Humans Child Escherichia coli Infections Escherichia coli infection Netherlands Retrospective Studies Family Health biology business.industry Infant Newborn Pathology of the hemolytic uremic syndrome Infant food and beverages medicine.disease Antibodies Bacterial Bloody Infectious Diseases chemistry VTEC Child Preschool Hemolytic-Uremic Syndrome Pediatrics Perinatology and Child Health Immunology biology.protein De pathologie van het hemolytisch uremisch syndroom Female medicine.symptom Antibody business human activities |
| Zdroj: | Pediatric Infectious Disease Journal, 18, 709-714 Pediatric Infectious Disease Journal, 18, pp. 709-714 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/00006454-199908000-00011 |
| Popis: | Background. Strains of verocytotoxin-producing Escherichia coli (VTEC) belonging to serogroup O157 (O157 VTEC) can cause a spectrum of disease that includes nonspecific diarrhea, hemorrhagic colitis and the diarrhea-associated form of the hemolytic uremic syndrome (D+ HUS). Methods. We conducted a retrospective study of 34 children with D+ HUS caused by O157 VTEC to determine the frequency of VTEC infection in their household members. Results. Gastrointestinal tract symptoms were reported in 1 or more household contacts of 17 (50%) of the 34 index cases. Of the 26 household members with gastrointestinal tract symptoms, 15 were parents and 11 were siblings. Evidence of VTEC infection was reported in 1 or more household contacts in 23 (68%) of the 34 families (in 46% of the siblings and in 28% of the parents). Nineteen (48%) siblings had a positive stool sample and in only 5 (12%) of the siblings IgM class serum antibodies to O157-lipopolysaccharide (LPS) were detected. Nineteen (31%) parents had a positive stool sample. Antibodies to O157-LPS were not detected in any of the parents. The occurrence of (bloody) diarrhea significantly correlated with the occurrence of IgM class serum antibodies to O157-LPS. Conclusions. It was concluded that household members of children with D+ HUS are often asymptomatically infected with O157 VTEC. Differences in the pathogenesis of the infection between infected individuals may be related to differences in the number of ingested O157 VTEC bacteria and to differences in susceptibility. |
| Databáze: | OpenAIRE |
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