Impulsivity characterization in the Roman high- and low-avoidance rat strains: behavioral and neurochemical differences
| Autor: | Adolf Tobeña, M.D. Escarabajal, Alberto Fernández-Teruel, M. Gomez, Cristina Suñol, Pilar Flores, Carmen Torres, Margarita Moreno, Leticia Campa, Fernando Sánchez-Santed, Diana Cardona |
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| Rok vydání: | 2010 |
| Předmět: |
Serial reaction time
Time Factors media_common.quotation_subject Drinking Behavior Striatum Nucleus accumbens Neuropsychological Tests Impulsivity Nucleus Accumbens Developmental psychology Neurochemical Reward Species Specificity medicine Avoidance Learning Reaction Time Animals Biogenic Monoamines media_common Pharmacology Addiction Novelty seeking Corpus Striatum Rats Psychiatry and Mental health Phenotype Impulsive Behavior Models Animal Anxiety Conditioning Operant Female Original Article medicine.symptom Psychology Neuroscience |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1740-634X |
| Popis: | The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies. © 2010 Nature Publishing Group All rights reserved. This work was supported by project SEJ2006-15226-C0201/PSIC, granted by the Ministerio de Ciencia e Innovación, subdirección general de proyectos de investigación and by FEDER funds. AF-T and AT receive support from EUR-ATools (European Commission Contract no. LSHG-CT-2005-019015), PSI2009-10532, and 2009-SGR-51. |
| Databáze: | OpenAIRE |
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