The Sperm Small RNA Transcriptome: Implications beyond Reproductive Disorder

Autor:	Sze Yan Chan, Crystal Wing Tung Wan, Tin Yu Samuel Law, David Yiu Leung Chan, Ellis Kin Lam Fok
Rok vydání:	2022
Předmět:	Inorganic Chemistry Organic Chemistry General Medicine Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications
Zdroj:	International journal of molecular sciences. 23(24)
ISSN:	1422-0067
Popis:	Apart from the paternal half of the genetic material, the male gamete carries assorted epigenetic marks for optimal fertilization and the developmental trajectory for the early embryo. Recent works showed dynamic changes in small noncoding RNA (sncRNA) in spermatozoa as they transit through the testicular environment to the epididymal segments. Studies demonstrated the changes to be mediated by epididymosomes during the transit through the adluminal duct in the epididymis, and the changes in sperm sncRNA content stemmed from environmental insults significantly altering the early embryo development and predisposing the offspring to metabolic disorders. Here, we review the current knowledge on the establishment of the sperm sncRNA transcriptome and their role in male-factor infertility, evidence of altered offspring health in response to the paternal life experiences through sperm sncRNA species and, finally, their implications in assisted reproductive technology in terms of epigenetic inheritance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc9230aec8a551b26b750b7e04a1af6 https://pubmed.ncbi.nlm.nih.gov/36555356 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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