Development of self-healing vanillin/PEI hydrogels for tissue engineering

Autor: Merve Yasar, Burcu Oktay, Fulya Dal Yontem, Ebru Haciosmanoglu Aldogan, Nilhan Kayaman Apohan
Přispěvatelé: Yasar M., OKTAY B., Dal Yontem F., Haciosmanoglu Aldogan E., KAYAMAN APOHAN N.
Rok vydání: 2023
Předmět:
Characterization of Polymers
Polymers and Plastics
Uzay bilimi
Temel Bilimler (SCI)
Self-healing
General Physics and Astronomy
POLYMER SCIENCE
MATERIALS SCIENCE
MULTIDISCIPLINARY
Astronomi ve Astrofizik
Fizik
Biochemistry
Physical Chemistry
MATERIALS SCIENCE
Organik Kimya
Kimya
Polimerler ve Plastikler
CHEMISTRY
KİMYA
ORGANİK
ASTRONOMİ VE ASTROFİZİK
Biyokimya
Materials Chemistry
UV-polymerization
Biyoinorganik Kimya
ASTRONOMY & ASTROPHYSICS
MALZEME BİLİMİ
ÇOKDİSİPLİNLİ
Engineering
Computing & Technology (ENG)
SPACE SCIENCE
Bioinorganic Chemistry
Malzeme Kimyası
Temel Bilimler
Physics
Polimer Karakterizasyonu
Organic Chemistry
Fizikokimya
Astronomy and Astrophysics
Mühendislik
Bilişim ve Teknoloji (ENG)
Hydrogels
CHEMISTRY
ORGANIC
Genel Fizik ve Astronomi
Fizik Bilimleri
POLİMER BİLİMİ
Natural Sciences (SCI)
Physical Sciences
Vanillin
Engineering and Technology
Mühendislik ve Teknoloji
Natural Sciences
Malzeme Bilimi
Zdroj: European Polymer Journal. 188:111933
ISSN: 0014-3057
Popis: Self-healing materials recover mechanical damages to expand the lifetime of the material provided. In this study, self-healing hydrogels have been successfully prepared using a novel and simple technique. Vanillin is a natural monomer, used as a bio-based cross-linker for UV-induced bonding and Schiff-base bonding. Methacrylate-functionalized vanillin (M-VAN) is covalently integrated with the polymer matrix. While M-VAN supports polymer matrix with its vinyl group, its aldehyde functionality helps the formation of dynamic covalent imine bonds via Schiff-base formation. The hydrogel showed excellent self-healing ability overnight under physiological conditions without external addition. In addition, the hydrogel surface was modified by collagen and its cell viability was investigated. The prepared scaffolds showed good cell viability of 124% and 163% compared to the control sample. The developed self-healing material reveals that it has possible uses for future biomedical applications and tissue engineering studies due to the self-healing mechanism taking place under ambient conditions.
Databáze: OpenAIRE
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