Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia
| Autor: | Urva Barot, Emma Price, Robert G. Kalb, Shachee Doshi, Justin Landis, Mariangela Sabatella, Hannes Lans |
|---|---|
| Přispěvatelé: | Molecular Genetics |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Nervous system Cell Longevity Regulator Neuropeptide Biochemistry Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Physiology (medical) medicine Animals Receptor Caenorhabditis elegans Caenorhabditis elegans Proteins Hypoxia Gene biology Gene Expression Profiling Calcium-Binding Proteins Neuropeptides Gene Expression Regulation Developmental biology.organism_classification Cell biology Oxygen 030104 developmental biology medicine.anatomical_structure Proprotein Convertase 2 030217 neurology & neurosurgery Hormone Signal Transduction |
| Zdroj: | Free Radical Biology and Medicine, 131, 197-208. Elsevier Inc. |
| ISSN: | 0891-5849 |
| DOI: | 10.1016/j.freeradbiomed.2018.12.006 |
| Popis: | Inadequate delivery of oxygen to organisms during development can lead to cell dysfunction/death and life-long disabilities. Although the susceptibility of developing cells to low oxygen conditions changes with maturation, the cellular and molecular pathways that govern responses to low oxygen are incompletely understood. Here we show that developing Caenorhabditis elegans are substantially more sensitive to anoxia than adult animals and that this sensitivity is controlled by nervous system generated hormones (e.g., neuropeptides). A screen of neuropeptide genes identified and validated nlp-40 and its receptor aex-2 as a key regulator of anoxic survival in developing worms. The survival-promoting action of impaired neuropeptide signaling does not rely on five known stress resistance pathways and is specific to anoxic insult. Together, these data highlight a novel cell non-autonomous pathway that regulates the susceptibility of developing organisms to anoxia. |
| Databáze: | OpenAIRE |
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