Analysis of risk factors influencing the BK polyomavirus replication in patients with ESRD waiting for kidney transplantation
| Autor: | Mohammad Shenagari, Amir Hassankhani, Foroogh Nazari Chamaki, Aydin Pourkazemi, Babak Ashrafkhani, Mohammadkazem Lebadi, Masoud Khosravi, Ali Shabestani Monfared |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment 030106 microbiology Viremia medicine.disease_cause Microbiology 03 medical and health sciences Renal Dialysis Risk Factors Internal medicine medicine Humans Survival rate Dialysis Kidney transplantation Aged Polyomavirus Infections business.industry Viral Load medicine.disease Kidney Transplantation BK virus Transplantation Tumor Virus Infections 030104 developmental biology Infectious Diseases Cross-Sectional Studies BK Virus Kidney Failure Chronic Hemodialysis business Viral load |
| Zdroj: | Microbial pathogenesis. 149 |
| ISSN: | 1096-1208 |
| Popis: | Background Since the pre-transplant status affects the renal transplantation success and ultimately the survival rate, identifying the probable risk factors that increase the chance of BK virus replication in end-stage renal disease patients can be included in proposing proper surveillance guidelines during pre and post-transplantation. Methods A descriptive cross-sectional study was performed by collecting plasma samples from 192 ESRD patients undergoing hemodialysis for at least 3 months. Quantitative Real-time PCR assay was used to detect and measure the BK viral load. Demographic and clinical characteristics of the patients who had BK viremia were documented. Results 14 (7.3%) out of our 192 participants had BK virus viremia (95%CI 4.2%–11.6%). Demographic characteristics including etiology of ESRD and underlying diseases, mean duration and frequency of dialysis, co-infection with HBV and HCV did not affect the virus replication, since the difference between patients with BK virus viremia and BK virus negative individuals was not statistically significant. However, the statistical significance of the mean age of men with BKV and without BK virus viremia was found (OR: 3.42, P = 0.02 95%CI 0.86–13.61). Also, multiple regression analyses of some other parameters revealed that old age, high body mass index and male gender can be predictive factors of BK virus viremia in ESRD patients. Conclusion Based on our findings, elderly male had higher chance of being exposed to BK virus viremia. Some other demographic characteristics such as a high BMI, old age and gender (male) can increase the risk of BK viremia in patients with ESRD prior to kidney transplantation. |
| Databáze: | OpenAIRE |
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