Population-based case-control teratologic study of topical miconazole
Autor: | Zoltán Kazy, Erzsébet Puhó, Andrew E. Czeizel |
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Rok vydání: | 2004 |
Předmět: |
Adult
Embryology Pediatrics medicine.medical_specialty Antifungal Agents Miconazole Administration Topical Population Skin infection Pregnancy medicine Humans Sex organ education education.field_of_study Fetus business.industry Case-control study Abnormalities Drug-Induced General Medicine medicine.disease Confidence interval Case-Control Studies Pediatrics Perinatology and Child Health Female business Developmental Biology medicine.drug |
Zdroj: | Congenital Anomalies. 44:41-45 |
ISSN: | 1741-4520 0914-3505 |
Popis: | Miconazole cream is used in Hungary to treat fungal genital and skin infections in pregnant women, but it causes anxiety for both patients and medical doctors due to the category C classification of the drug regarding teratogenic or fetotoxic risk. The objective of this case-control study was to analyze the teratogenic potential of topical miconazole used during pregnancy in the mothers of babies with congenital abnormalities and in matched control mothers of babies without congenital abnormalities. The population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities between 1980 and 1996 included 22 843 women who had newborns or fetuses with congenital abnormalities, and 38 151 pregnant women who had newborn infants without any defects (controls). In the case group, 24 (0.11%) and in the control group, 46 (0.12%) pregnant women were treated with miconazole (crude odd ratio [OR]: 0.9 with 95% confidence interval [CI]: 0.6-1.6). Different congenital abnormality groups were evaluated in case-control pairs and a higher prevalence of miconazole treatment was not found during the second or third month of pregnancy. Thus, treatment with topical miconazole during pregnancy does not increase the risk of congenital abnormalities. |
Databáze: | OpenAIRE |
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