Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm

Autor:	Edward D. Levin, Rose Schrott, Erica Pippen, Nilda Itchon-Ramos, Susan K. Murphy, Kelly S. Acharya, John T. Mitchell, Andrew B. Hawkey, Scott H. Kollins
Rok vydání:	2019
Předmět:	Adult Male 0301 basic medicine Marijuana Abuse Cancer Research Candidate gene Adolescent Offspring autism Nerve Tissue Proteins heritability sperm Nucleus Accumbens Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Dronabinol Autistic Disorder Molecular Biology Cannabis Cannabinoid Receptor Agonists Genetics DNA methylation biology Representation (systemics) Heritability biology.organism_classification medicine.disease Spermatozoa Phenotype Introns Rats 030104 developmental biology 030220 oncology & carcinogenesis Autism CpG Islands Research Paper
Zdroj:	Epigenetics
ISSN:	1559-2308 1559-2294
Popis:	Parental cannabis use has been associated with adverse neurodevelopmental outcomes in offspring, but how such phenotypes are transmitted is largely unknown. Using reduced representation bisulphite sequencing (RRBS), we recently demonstrated that cannabis use is associated with widespread DNA methylation changes in human and rat sperm. Discs-Large Associated Protein 2 (DLGAP2), involved in synapse organization, neuronal signaling, and strongly implicated in autism, exhibited significant hypomethylation (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc3c102cc340b740bbbb41d265eb64d https://doi.org/10.1080/15592294.2019.1656158 Zobrazit plný text záznamu