A comparison of alternate immunization regimes for measles in vaccinated populations
| Autor: | Henry F. Pabst, Mary M. Carson, Paul Boothe |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Vaccination schedule
Population Measles Vaccine Antibodies Viral Measles Alberta Neutralization Tests Pregnancy Medicine Humans Seroconversion education Immunization Schedule education.field_of_study General Veterinary General Immunology and Microbiology business.industry Public Health Environmental and Occupational Health Infant medicine.disease Vaccination Infectious Diseases Immunization Measles virus Immunology Costs and Cost Analysis Molecular Medicine Population study Female Viral disease business Immunity Maternally-Acquired Demography |
| Zdroj: | Vaccine. 17(2) |
| ISSN: | 0264-410X |
| Popis: | Infants today lose maternal measles antibody sooner than in the past. This is related to demographic changes in maternal immunization. Data for rates of decay of maternal antibody and seroconversion after measles vaccination for infants born to naturally immune (Group 1) or vaccinated (Group 2) mothers have been used to evaluate two vaccination schedules: Regime 1, measles–mumps–rubella (MMR) at 1 year of age and Regime 2, monovalent measles at 6 months followed by MMR at 15 months of age. Regime 2 costs less because MMR can be administered at 15 months with the last pentavalent booster. Months of protection/1000 children aged 0–15 months (child-months of protection) were estimated for infant populations ranging from 0 to 100% Group 1 for Regimes 1 and 2. Regime 1 provides more child-months of protection only for 100% Group 1 populations. For the study population Regime 2 provided at least 17% more child-months of protection than Regime 1. Regime 2 provides increased medical and financial benefits in proportion to the number of Group 2 infants in the population and thus is ever more advantageous for today's increasingly vaccinated populations. |
| Databáze: | OpenAIRE |
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