Expression of c-erbB-2 protein and epidermal growth factor receptor in normal tissues of the female genital tract and in the placenta
| Autor: | Da peng Wang, Hirofumi Nonogaki, Ikuo Konishi, Shingo Fujii, Toshiko Iwai, Takahide Mori, Yoshihiko Nanbu |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Stromal cell Receptor ErbB-2 Placenta Biology Endometrium Pathology and Forensic Medicine Andrology Growth factor receptor Reference Values Epidermal growth factor Proto-Oncogene Proteins Internal medicine Proto-Oncogenes medicine Humans Tissue Distribution Epidermal growth factor receptor Molecular Biology reproductive and urinary physiology Staining and Labeling Decidualization Genitalia Female Cell Biology General Medicine Immunohistochemistry ErbB Receptors Endocrinology medicine.anatomical_structure embryonic structures biology.protein Female Menopause |
| Zdroj: | Virchows Archiv A Pathological Anatomy and Histopathology. 420:385-393 |
| ISSN: | 1432-2307 0174-7398 |
| DOI: | 10.1007/bf01600509 |
| Popis: | The c-erbB-2 (HER-2/neu) protein is a membrane glycoprotein growth factor receptor that has molecular homology with the epidermal growth factor receptor (EGFR). To investigate the relationship between the expression of c-erbB-2 protein and EGFR in the tissues of the human female genital tract and in the placenta, we examined the immunohistochemical reactivity of monoclonal antibodies against both of these proteins. In the müllerian-derived genital tract, epithelial cells of the fallopian tube, endometrium, and endocervix showed reactivity for c-erbB-2 protein, whereas reactivity for EGFR was distributed mainly in the stromal cells throughout the menstrual cycle and during pregnancy. In addition, the staining intensity for EGFR in the endometrial stroma increased with its decidualization. In the exocervical squamous epithelium, basal cells were c-erbB-2 protein-negative and EGFR-positive, but the more differentiated squamous cells of the intermediate layer were c-erbB-2 protein-positive and EGFR-negative. In the placental tissues, cytotrophoblasts and syncytiotrophoblasts of the chorionic villi were c-erbB-2 protein-negative and EGFR-positive. In contrast, intermediate trophoblasts in the extravillous space were c-erbB-2 protein-positive and EGFR-negative. Thus, there is an inverse relationship between the expression of c-erbB-2 protein and EGFR in the tissues of the female genital tract and in the placenta. This suggests that there may be a regulatory mechanism(s) for the expression of both proteins that is associated with the differentiation and/or function of cells in the female genital tract and the placenta. |
| Databáze: | OpenAIRE |
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