Synovial expression of cell adhesion molecules in polymyalgia rheumatica
| Autor: | L. Frizziero, Andrea Facchini, Pierluigi Macchioni, Carlo Salvarani, Mariagrazia Uguccioni, Riccardo Meliconi, Lia Pulsatelli, Maria Cristina Focherini, Cinzia Melchiorri |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cell type Aged Aged 80 and over Cell Adhesion Molecules Cell Movement Endothelium Vascular Female Humans Middle Aged Polymyalgia Rheumatica Synovial Membrane Immunology Adhesion (medicine) Polymyalgia rheumatica Pathogenesis Synovitis Vascular medicine 80 and over Immunology and Allergy Endothelium Cell adhesion Cell adhesion molecule business.industry medicine.disease medicine.anatomical_structure Synovial membrane business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1046/j.1365-2249.1997.00294.x |
| Popis: | SUMMARY Polymyalgia rheumatica (PMR) is a common disorder of the elderly: the pathogenesis of the syndrome is still debated, though active synovitis of the shoulder has recently been confirmed. To investigate the pathogenesis of this synovitis we evaluated cell adhesion molecule (CAM) expression in shoulder synovial tissue from patients with PMR, correlated synovial expression with the serum levels of soluble forms, and assessed the changes associated with corticosteroid treatment. Arthroscopic synovial biopsies were obtained from 12 untreated and seven corticosteroid (CS)-treated cases. CAM expression was evaluated by MoAb staining on frozen sections and computerized image analysis. Soluble CAM were quantified by ELISA. Endothelial cells expressed intercellular adhesion molecule-1 (ICAM-l), E- and P-selectins. Infiltrating cells were ICAM-1 and β1-integrin-positive, while L-selectin expression was limited to intravascular leucocytes. Synovial lining cells strongly expressed vascular cell adhesion molecule-1 (VCAM-1), and less intensely ICAM-1. Only the soluble form of ICAM-1 (sICAM-1) was elevated in untreated patients. CS treatment was associated with a decrease in ICAM-1, VCAM-1 and E- and P-selectin expression. sICAM-1 levels were in the normal range in treated patients. VLA-5 and 6 expression was widely distributed among cell types, and was not CS-sensitive. Active shoulder synovitis is associated with different CAM expression in PMR. ICAM-l expression is widely distributed and correlates with elevated levels of the soluble form; it is significantly lower in CS-treated asymptomatic cases. |
| Databáze: | OpenAIRE |
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