Hepatitis B virus infection among institutionalized mentally ill patients in Brazil
| Autor: | Fabíola Souza Fiaccadori, Divina das Dôres de Paula Cardoso, Tâmera Nunes Vieira Almeida, Marielton dos Passos Cunha, Tatiane Cinquini Moraes, Menira Souza, Ítalo de Araújo Castro |
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| Rok vydání: | 2015 |
| Předmět: |
Hospitals
Psychiatric Male HBsAg Occult infection lcsh:QR1-502 medicine.disease_cause Polymerase Chain Reaction lcsh:Microbiology Serology law.invention Risk Factors law Genotype Prevalence Child Polymerase chain reaction Aged 80 and over Medicine(all) Transmission (medicine) virus diseases Middle Aged Hepatitis B Vaccination Infectious Diseases Mental illness Child Preschool Female Brazil Adult Microbiology (medical) Hepatitis B virus Adolescent Enzyme-Linked Immunosorbent Assay lcsh:Infectious and parasitic diseases Young Adult Mentally Ill Persons medicine Humans lcsh:RC109-216 Hepatitis B Antibodies Aged Hepatitis B Surface Antigens business.industry medicine.disease Virology digestive system diseases DNA Viral business |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 19, Iss 6, Pp 643-647 (2015) Brazilian Journal of Infectious Diseases, Volume: 19, Issue: 6, Pages: 643-647, Published: DEC 2015 |
| ISSN: | 1413-8670 |
| Popis: | Objectives: The main objective was to evaluate HBV infection and occult HBV infection (OBI) cases in mentally ill patients based on serological and molecular profiles. Material and methods: Serum samples of 333 long-stay mentally ill patients were tested for the prevalence of HBV markers by serological (ELISA) and molecular (PCR) assays. The PCR products were sequenced to determine viral genotypes. Results: It was observed a global prevalence of 12.9% (43/333) for HBV infection markers, considering HBsAg and/or anti-HBc positivity. Fourteen samples tested positive for anti-HBs alone. All samples positive (n = 57) for any HBV serological markers were tested for HBV-DNA and six were positive: HBsAg/anti-HBc (n = 1), anti-HBc/anti-HBs (n = 1), anti-HBs alone (n = 1), and anti-HBc alone (n = 3). The rate of OBI was 9.2% (5/54) from samples that were anti-HBc and/or anti-HBs positive. All sequenced samples were characterized as genotype A. Conclusion: The high rate of HBV infections found in this study suggests the possibility of HBV transmission due to risk factors displayed by some patients, and highlights the importance of vaccination of susceptible patients and the staff of that institution. Keywords: Hepatitis B virus, Occult infection, Prevalence, Mental illness |
| Databáze: | OpenAIRE |
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