Practical Approaches to Low Density Lipoprotein Oxidation: Whys, Wherefores and Pitfalls
| Autor: | Catherine Rice-Evans, K. Richard Bruckdorfer, David S. Leake, Anthony T. Diplock |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Iron
Conjugated system Biochemistry Fluorescence Lipid peroxidation chemistry.chemical_compound Low density Animals Humans Organic chemistry Electrophoresis Agar Gel Nitrates Lipid Hydroperoxide Macrophages Critical factors Reproducibility of Results General Medicine Chromatography Ion Exchange Combinatorial chemistry Transition metal ions Lipoproteins LDL Glucose chemistry Metals Low-density lipoprotein Electrophoresis Polyacrylamide Gel Lipid Peroxidation Azo Compounds Oxidation-Reduction Peroxynitrite |
| Zdroj: | Free Radical Research. 25:285-311 |
| ISSN: | 1029-2470 1071-5762 |
| DOI: | 10.3109/10715769609149053 |
| Popis: | The purpose of this review is to bring together the different approaches for studying the oxidation of low density lipoproteins and try to identify some critical factors which will permit greater comparability between laboratories. These issues are discussed both in terms of the variety of exogenous mediators of oxidation applied (transition metal ions, haem proteins, azo initiators, peroxynitrite, cells etc.) and their raisons d'être, as well as the methodologies (formation of conjugated dienes, hydroperoxides, decomposition products of lipid peroxidation, altered surface charge, macrophage uptake) applicable to the different stages of the oxidation and the factors underlying their accurate execution and interpretation. |
| Databáze: | OpenAIRE |
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