Booster immunity - diagnosis of chronic hepatitis B viral infection
| Autor: | Aneta V Ivanova, Maria V. Atanasova, Ani Kevorkyan, R. Komitova, Elica Golkocheva-Markova |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male HBsAg Hepatitis B virus Hepatitis B vaccine medicine.disease_cause Microbiology Disease Outbreaks Hepatitis B Antigens 03 medical and health sciences 0302 clinical medicine Hepatitis B Chronic Virology medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies Family Health business.industry virus diseases Hepatitis A General Medicine Hepatitis C Hepatitis B Middle Aged medicine.disease digestive system diseases Vaccination HBcAg 030104 developmental biology Infectious Diseases DNA Viral 030211 gastroenterology & hepatology Parasitology Female business |
| Zdroj: | Journal of infection in developing countries. 13(3) |
| ISSN: | 1972-2680 |
| Popis: | Introduction: Diagnosis of chronic hepatitis B virus (HBV) infection particularly its occult form requires monitoring and repeat serological and molecular studies. The aim of the study was to investigate the possible relation between the case of a family outbreak of hepatitis A and the finding that a member of this family was diagnosed with chronic hepatitis B. Methodology: A mother and her two sons, one previously diagnosed with chronic HBV infection, were hospitalized due to suspected acute hepatitis. Serological markers for hepatitis A, hepatitis B and hepatitis C were assessed. Additionally, HBV DNA was tested with a sensitive PCR. Hepatitis B vaccine was administered to the mother to differentiate resolved from occult HBV infection. Results: A family outbreak of hepatitis A was confirmed, alongside a focus of chronic HBV infection. The serological profile for two brothers was HBsAg(+), anti-HBcIgM(-), anti-HBc(+), HBcAg(-)/anti-HBe(+). The mother was negative for all HBV markers except anti-HBc. HBV DNA was detected at a level of 461 IU/mL in the elder brother, 3647 IU/mL in the younger brother and was negative in the mother on two occasions. Her anti-HBc alone, having two sons with chronic HBV infection, and her lack of antibody response to hepatitis B vaccine despite being negative for HBV DNA, led to the diagnosis of probable occult HBV infection. Conclusion: Our results confirmed that a vaccination approach could facilitate diagnosis of chronic HBV infection in the presence of isolated anti-HBc. If it were not for a family outbreak of hepatitis A, this unexpected family HBV focus would not have been revealed. |
| Databáze: | OpenAIRE |
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