Pyothorax-associated lymphoma (PAL): a western case with marked angiocentricity and review of the literature
| Autor: | T. Dosios, D Hatzianastassiou, S Vgenopoulou, Maria Gazouli, P Korkolopoulou, Elias Drakos, E. Patsouris, Athina Androulaki |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Epstein-Barr Virus Infections Herpesvirus 4 Human Pathology medicine.medical_specialty Lymphoma B-Cell Histology Pleural effusion Pleural Neoplasms medicine.disease_cause Virus Herpesviridae Pathology and Forensic Medicine Pleural Lymphoma Pyothorax-Associated Lymphoma Fatal Outcome hemic and lymphatic diseases Biomarkers Tumor medicine Humans Gammaherpesvirinae Empyema Pleural In Situ Hybridization Aged Greece biology business.industry General Medicine medicine.disease biology.organism_classification Epstein–Barr virus Vascular Neoplasms Lymphoma RNA Viral business |
| Zdroj: | Histopathology. 44:69-76 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1111/j.1365-2559.2004.01737.x |
| Popis: | Aims To report a case of pyothorax-associated lymphoma in a non-immunocompromised 78-year-old man with a 45-year history of tuberculous pleuritis and left pleural effusion. Pyothorax-associated lymphoma is a high-grade non-Hodgkin's lymphoma occurring in 2% of patients with long-standing tuberculous pleuritis and pyothorax. Pyothorax-associated lymphoma is frequently Epstein-Barr virus (EBV)-associated, mainly reported in Japan but exceedingly rare in western countries. Methods and results Histology revealed a high-grade, diffuse large B-cell lymphoma with immunoblastic and plasmacytoid features and marked angiocentricity with focal destruction of the vessel walls. Immunohistochemistry revealed a post germinal B-cell phenotype. RNA in-situ hybridization and molecular analysis showed a latent EBV infection and absence of human herpes virus-8 (HHV-8). Conclusions Pyothorax-associated lymphoma represents a rare but distinctive type of diffuse large B-cell lymphoma, with characteristic clinico-epidemiological, immunohistological, and biological features. |
| Databáze: | OpenAIRE |
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