Potentially increased sensitivity of pregnant and lactating female rats to immunotoxic agents
| Autor: | Joost P. Bruijntjes, C. Frieke Kuper, Ine Waalkens, Andre Wolterbeek, Didima de Groot, Cor Snel, Lidy van Oostrum, Aswin Menke |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Neutrophils Life Triskelion lactation Thymus Gland Toxicology Deoxycytidine Pathology and Forensic Medicine Immune system thymus Pregnancy Internal medicine Lactation EELS - Earth Environmental and Life Sciences TNO Bedrijven Sensitive periods medicine sensitive periods Weaning Animals Thymus weight Rats Wistar Continuous exposure Molecular Biology Biology immunotoxicity Thionucleosides business.industry Immunotoxins Cell Biology medicine.disease Acquired immune system Rats DOTC Endocrinology medicine.anatomical_structure Female pregnancy Healthy for Life QS - Quality & Safety business Healthy Living Spleen |
| Zdroj: | Toxicologic Pathology, 2, 40, 255-260 |
| ISSN: | 1533-1601 |
| Popis: | Characteristic susceptibility to environmental and pharmaceutical exposure may occur during periods in life of marked histophysiological changes of the immune system. Perinatal development is such a period; pregnancy followed by lactation is potentially another one. Here, we explored the influence of pregnancy and lactation on the model immunotoxic compound di-n-octyltin dichloride (DOTC) in rats using clinical and histopathological parameters. Female rats were exposed to 0, 3, 10, or 30 mg DOTC/kg feed during pregnancy and up to 20 (at weaning) or 56 days after delivery. Age-matched nonmated females were exposed during the same time periods. DOTC at the level of 10 and 30 mg/kg decreased thymus weight and affected thymus morphology in the lactating rats. In addition, DOTC decreased the numbers of neutrophils in the lactating rats. These effects were no longer apparent at day 56 despite continuous exposure to DOTC. This explorative study indicates that the innate and adaptive immune system may be especially sensitive to immunotoxicants during pregnancy and lactation. © 2012 Society of Toxicologic Pathology. |
| Databáze: | OpenAIRE |
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