Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors
| Autor: | Matthias J. Reddehase, Wolfgang Mutter, Ulrich Koszinowski, Frank Weiland, Stipan Jonjić |
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| Rok vydání: | 1988 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Adoptive cell transfer Adrenalitis T-Lymphocytes medicine.medical_treatment Immunology Adrenal Gland Diseases Mice Nude Spleen Biology Microbiology Virus Mice Virology Adrenal Glands MCMV CD4 lymphocytes CD8 lymphocytes adoptive transfer medicine Animals Lung Mice Inbred BALB C Effector Immunization Passive Immunologic Deficiency Syndromes T lymphocyte Immunotherapy medicine.anatomical_structure Insect Science Chronic Disease Cytomegalovirus Infections Immunologic Memory CD8 Research Article |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.62.3.1061-1065.1988 |
| Popis: | The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments. At a stage of pathogenesis when virus had already colonized target tissues, a therapeutic antiviral function could be ascribed to the CD8+ subset. This in vivo function was not restricted to sites in which intravenously infused lymphocytes usually are trapped or home in, such as the lungs or the spleen, respectively, but was also evident in the adrenal glands, a site to which antiviral effector cells have to specifically migrate. Specific infiltration of adrenal gland cortical tissue by donor-derived CD8+ memory T lymphocytes was demonstrated. CD4+ memory T lymphocytes had no antiviral effect by themselves and also were not required for the function of the CD8+ effector cells in this short-term immunotherapy model. These findings should help settle the debate about which subset of T lymphocytes comprises the effector cells that can directly control cytomegalovirus infection in the murine model system. |
| Databáze: | OpenAIRE |
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