Long Non-Coding RNA (lncRNA) X-Inactive Specific Transcript (XIST) Plays a Critical Role in Predicting Clinical Prognosis and Progression of Colorectal Cancer
| Autor: | Sheng-Xue Pan, Zong-Bu Yu, Qing-Yin Kong, Ai-Hua Wang, Kai-Tong Jiang, Xiu-Tian Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Oncology medicine.medical_specialty Colorectal cancer 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Lab/In Vitro Research Cell Line Tumor Internal medicine medicine Humans Stage (cooking) Risk factor neoplasms Regulation of gene expression business.industry Proportional hazards model RNA General Medicine Middle Aged Prognosis medicine.disease digestive system diseases Long non-coding RNA Up-Regulation Gene Expression Regulation Neoplastic 030220 oncology & carcinogenesis Disease Progression Female RNA Long Noncoding XIST Colorectal Neoplasms business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.915329 |
| Popis: | BACKGROUND Long non-coding RNAs (lncRNAs) participate in all cancer biology processes of cells. Although functions and associated mechanisms of lncRNAs have been proven in colorectal cancer (CRC), the roles of lncRNA X-inactive specific transcript (XIST) have not been clearly investigated in CRC. MATERIAL AND METHODS Expression of XIST was detected by quantitative real-time PCR (qRT-PCR) assay in CRC cell lines and 196 clinical samples. Correlations between XIST expression and CRC clinicopathological features were analyzed. Log-rank test and Kaplan-Meier test were performed to assess and compare the prognoses of patients with higher and lower expression of XIST. The multivariate Cox regression and univariate Cox regression were conducted to evaluate the risk factors for prognosis of CRC. RESULTS lncRNA XIST was upregulated in CRC cells lines and tissues (p |
| Databáze: | OpenAIRE |
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