GRM7 polymorphisms and risk of schizophrenia in Iranian population
Autor: | Rezvan Noroozi, Hamid Fallah, Mohammad Taheri, Iman Azari, Reza Hosseinpour Moghadam, Soudeh Ghafouri-Fard |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Genotype Single-nucleotide polymorphism Iran Receptors Metabotropic Glutamate Polymorphism Single Nucleotide Biochemistry Pathogenesis 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Gene Frequency Polymorphism (computer science) Internal medicine medicine Humans SNP Genetic Predisposition to Disease Allele Alleles business.industry Middle Aged medicine.disease Genotype frequency 030104 developmental biology Schizophrenia Metabotropic glutamate receptor Female Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Metabolic Brain Disease. 34:847-852 |
ISSN: | 1573-7365 0885-7490 |
DOI: | 10.1007/s11011-018-0380-6 |
Popis: | The role of metabotropic glutamate receptors in the pathogenesis of schizophrenia or response to antipsychotic treatment has been proposed previously. The aim of the current study was to investigate the associations between two intronic variants within GRM7 gene (rs6782011 and rs779867) and schizophrenia in Iranian population. These two single nucleotide polymorphisms (SNPs) were genotyped in 273 schizophrenic patients and 300 age and sex-matched normal controls. The frequency of A allele of the rs779867 was significantly lower in the schizophrenic patients compared with healthy subjects (OR (95% CI) = 0.71 (0.56-0.89), adjusted P value = 0.008). This SNP was associated with schizophrenia in co-dominant and dominant models (adjusted P values of 0.03 and 0.02 respectively). However, there was no difference in allele and genotype frequencies of the rs6782011 SNP between cases and controls. Consequently, the results of current study further highlight the participation of GRM7 in the pathogenesis of schizophrenia. |
Databáze: | OpenAIRE |
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