GRM7 polymorphisms and risk of schizophrenia in Iranian population

Autor: Rezvan Noroozi, Hamid Fallah, Mohammad Taheri, Iman Azari, Reza Hosseinpour Moghadam, Soudeh Ghafouri-Fard
Rok vydání: 2019
Předmět:
Zdroj: Metabolic Brain Disease. 34:847-852
ISSN: 1573-7365
0885-7490
DOI: 10.1007/s11011-018-0380-6
Popis: The role of metabotropic glutamate receptors in the pathogenesis of schizophrenia or response to antipsychotic treatment has been proposed previously. The aim of the current study was to investigate the associations between two intronic variants within GRM7 gene (rs6782011 and rs779867) and schizophrenia in Iranian population. These two single nucleotide polymorphisms (SNPs) were genotyped in 273 schizophrenic patients and 300 age and sex-matched normal controls. The frequency of A allele of the rs779867 was significantly lower in the schizophrenic patients compared with healthy subjects (OR (95% CI) = 0.71 (0.56-0.89), adjusted P value = 0.008). This SNP was associated with schizophrenia in co-dominant and dominant models (adjusted P values of 0.03 and 0.02 respectively). However, there was no difference in allele and genotype frequencies of the rs6782011 SNP between cases and controls. Consequently, the results of current study further highlight the participation of GRM7 in the pathogenesis of schizophrenia.
Databáze: OpenAIRE