Proliferative and Apoptotic Responses in Cancers With Special Reference To Oral Cancers
| Autor: | L. Krebs, Angela R. Kamer, S.A. Hoghooghi, Charles Liebow |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
0301 basic medicine
Apoptosis Biology Receptor tyrosine kinase 03 medical and health sciences 0302 clinical medicine Phosphoprotein Phosphatases medicine Animals Humans Genes Tumor Suppressor Phosphorylation Growth Substances General Dentistry Regulation of gene expression Kinase Cancer 030206 dentistry medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Otorhinolaryngology Carcinoma Squamous Cell biology.protein Cancer research Mouth Neoplasms Signal transduction Protein Kinases Tyrosine kinase Cell Division Platelet-derived growth factor receptor Signal Transduction |
| Zdroj: | Critical Reviews in Oral Biology & Medicine. 10:58-78 |
| ISSN: | 1544-1113 1045-4411 |
| DOI: | 10.1177/10454411990100010301 |
| Popis: | The study of signal transduction pathways for mechanisms of apoptosis and proliferation has significantly advanced our understanding of human cancer, subsequently leading to more effective treatments. Discoveries of growth factors and oncogenes, especially those that function through phosphorylation on tyrosine residues, have greatly benefited our appreciation of the biology of cancer. The regulation of proliferation and apoptosis through phosphorylation via tyrosine kinases and phosphatases is discussed, as well as the contributions of other systems, such as serine and threonine kinases and phosphatases. Receptors with seven-transmembrane domains, steroid hormones, genes, and "death domains" will also be discussed. This review attempts to compare the regulation of the growth of normal tissues and cancers with an effort to highlight the current knowledge of these factors in the growth regulation of oral/oropharyngeal cancers. Despite the strides made in our understanding of growth regulation in human cancers, the study of oral/oropharyngeal cancer specifically lags behind. More research must be done to further our understanding of oral cancer biology, if we are to develop better, more effective treatment protocols. |
| Databáze: | OpenAIRE |
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