Application of a computer-assisted high-performance liquid chromatographic multi-wavelength ultraviolet detection system to simultaneous toxicological drug analyses
| Autor: | Tokinori Watanabe, Makiko Hayashida, Makoto Nihira, Kiyokatsu Jinno |
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| Rok vydání: | 1990 |
| Předmět: |
Drug
Adult Male media_common.quotation_subject Multi wavelength medicine.disease_cause Toxicology Biochemistry Analytical Chemistry Japan medicine Humans Chromatography High Pressure Liquid media_common Detection limit Chromatography Chemistry Poisoning Organic Chemistry General Medicine Middle Aged Antidepressive Agents Anti-Anxiety Agents Clinical diagnosis Anticonvulsants Female Spectrophotometry Ultraviolet Uv detection Retention time Quantitative analysis (chemistry) Ultraviolet Software Antipsychotic Agents |
| Zdroj: | Journal of chromatography. 506 |
| Popis: | An emergency drug screening system for the separation and identification of toxic drugs, MULTI-HPLC, is presented. Chromatographic peaks, which were impossible to identify with a conventional high-performance liquid chromatographic UV detection system, became distinguishable by the spectral search and retention prediction of the data-processing program MCASYST. Sixty-five toxic drugs, frequently identified in drug poisonings in Japan, were selected as references in the drug library. Retention time, optimum detection wavelength, detection limit and recoveries from serum and urine were listed. Possible applications of the system are demonstrated, using gastric contents, sera and urines in cases of multiple drug ingestion. Quantitative analysis was sufficiently sensitive and precise to permit clinical diagnosis with increased accuracy. |
| Databáze: | OpenAIRE |
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