Cutaneous leucocytoclastic vasculitis secondary to cabozantinib therapy for renal cell carcinoma

Autor:	J E Sutton, G S Coltart, Simon J. Crabb, Matthew Sommerlad, Eugene Healy, H J Roche
Rok vydání:	2021
Předmět:	Leucocytoclastic vasculitis medicine.medical_specialty Cabozantinib business.industry First line Dermatology medicine.disease Rash 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Clear cell renal cell carcinoma 0302 clinical medicine medicine.anatomical_structure chemistry Renal cell carcinoma 030220 oncology & carcinogenesis medicine Abdomen Once daily medicine.symptom business
Zdroj:	Clinical and Experimental Dermatology. 46:739-740
ISSN:	1365-2230 0307-6938
DOI:	10.1111/ced.14541
Popis:	A 54-year old male with newly diagnosed poor-risk metastatic clear cell renal cell carcinoma (ccRCC) was started on first line palliative cabozantinib, 60mg once daily. Five weeks after commencing treatment, he developed "red spots" on his lower legs. On examination, he had multiple purpuric papules, predominantly distributed over his lower legs, with scattered lesions over his thighs and lower abdomen. Some of these papules subsequently developed superficial ulceration with purulent exudate. The clinical appearances were consistent with a cutaneous vasculitis with superficial bacterial infection (Figure 1). Cabozantinib was discontinued, however the rash continued to progress over the next 3 weeks.
Databáze:	OpenAIRE
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