Nephrotoxic effects of mercury exposure and smoking among Egyptian workers in a fluorescent lamp factory
| Autor: | Shouman Ae, Nour E Amin, Ibrahim A.M EL-Safty |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Time Factors Urinary system Statistics as Topic Physiology chemistry.chemical_element Kidney Mercury poisoning Nephrotoxicity Toxicology chemistry.chemical_compound Occupational Exposure Medicine Humans Maximum Allowable Concentration Morning Creatinine business.industry Smoking General Medicine Mercury medicine.disease Mercury (element) medicine.anatomical_structure chemistry Mercury Poisoning Egypt business Environmental Monitoring |
| Zdroj: | Archives of medical research. 34(1) |
| ISSN: | 0188-4409 |
| Popis: | Background It is known that mercury (Hg) has a nephrotoxic effect in exposed workers. This effect is evident when there is advanced damage of kidney tissue. Methods A random morning urine sample was collected from each participant for measuring urinary concentrations of total protein (UTP), retinol-binding protein (URBP), creatinine (UCr), Hg (UHg), and the activities of leucine-aminopeptidase (ULAP) and glutathione S-transferase (UGST) as well as N-acetyl-β-D-glucosaminidase (UNAG). Results Urinary excretion of the measured parameters was significantly increased among Hg-exposed workers who were smokers and among Hg-exposed workers with work duration ≥11 years than those with ≤10 years work duration. Conclusions Results of this investigation demonstrated that these urinary parameters of kidney integrity could be used as indicators of nephrotoxic effect of Hg exposure and that cigarette smoking has toxic and synergistic effects with Hg exposure on kidney. Present results additionally suggest reduction in recommended biological threshold limit (50 μg Hg/g Ucr) or biological exposure index (35 μg Hg/g Ucr) of urinary mercury levels because elevated levels of measured parameters were observed at urinary Hg levels of 17.3–28.2 μg Hg/g Ucr. |
| Databáze: | OpenAIRE |
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