Neural substrates for anticipation and consumption of social and monetary incentives in depression

Autor: Rebecca Elliott, Nils Muhlert, Zhenhong He, Dandan Zhang
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Cerebral Cortex/physiopathology
Motivation/physiology
Cognitive Neuroscience
Original Manuscript
Experimental and Cognitive Psychology
Audiology
insula
Gyrus Cinguli
behavioral disciplines and activities
Young Adult
Reward
medicine
Humans
Young adult
Anticipation
Psychological/physiology
Social Behavior
Depression/physiopathology
Depression (differential diagnoses)
Anterior cingulate cortex
Cerebral Cortex
Motivation
medicine.diagnostic_test
subgenual cingulate cortex
Depression
Putamen
Gyrus Cinguli/physiopathology
Putamen/physiopathology
General Medicine
Anticipation
Psychological
Magnetic Resonance Imaging
Anticipation
Incentive
medicine.anatomical_structure
social incentive
ventral lateral pre-frontal cortex
anticipation
Female
Psychology
Functional magnetic resonance imaging
Insula
psychological phenomena and processes
Zdroj: He, Z, Zhang, D, Muhlert, N & Elliott, R 2019, ' Neural substrates for anticipation and consumption of social and monetary incentives in depression ', Social Cognitive and Affective Neuroscience, vol. 14, no. 8, pp. 815-826 . https://doi.org/10.1093/scan/nsz061
Social Cognitive and Affective Neuroscience
ISSN: 1749-5024
1749-5016
DOI: 10.1093/scan/nsz061
Popis: Depression has been reliably associated with abnormalities in the neural representation of reward and loss. However, most studies have focused on monetary incentives; fewer studies have considered neural representation of social incentives. A direct comparison of non-social and social incentives within the same study would establish whether responses to the different incentives are differentially affected in depression. The functional magnetic resonance imaging study presented here investigated the neural activity of individuals with subthreshold depression (SD) and healthy controls (HCs) while they participated in an incentive delay task offering two types of reward (monetary gain vs social approval) and loss (monetary loss vs social disapproval). Compared to HCs, individuals with SD showed increased subgenual anterior cingulate cortex (sgACC) activity during anticipation of social loss, whereas the response in the putamen was decreased during consumption of social gain. Individuals with SD also exhibited diminished insula responses in consuming social loss. Furthermore, positive connectivity between the insula and ventral lateral pre-frontal cortex (VLPFC) was observed in individuals with SD while negative connectivity was found in HCs when consuming social loss. These results demonstrate neural alterations in individuals with depression, specific to the processing of social incentives, mainly characterised by dysfunction within the ‘social pain network’ (sgACC, insula and VLPFC).
Databáze: OpenAIRE
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