Improved nTMS- and DTI-derived CST tractography through anatomical ROI seeding on anterior pontine level compared to internal capsule
| Autor: | Irada Tursunova, AK Rehme, Volker Neuschmelting, Charlotte Nettekoven, Carolin Weiss, N. Jon Shah, Roland Goldbrunner, Ana-Maria Oros-Peusquens, Hannah Lockau, Christian Grefkes, Karl-Josef Langen, Gabriele Stoffels, Andrea Faymonville |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Internal capsule medicine.medical_treatment pxsq p-value according to Pearson's chi-square test Pyramidal Tracts Brain mapping lcsh:RC346-429 BOLD blood oxygenation level dependent nTMS AUC area under the curve aiP anterior inferior pons LDA/C linear discriminant analysis/coefficient Internal Capsule Pons Image Processing Computer-Assisted PM plantar muscle CST corticospinal tract ANOVA analysis of variance Brain Mapping Brain Neoplasms ROI Regular Article ROI region-of-interest Anatomy RMT resting motor threshold Transcranial Magnetic Stimulation APB abductor pollicis brevis muscle medicine.anatomical_structure Diffusion Tensor Imaging Neurology DTI FOV field-of-view lcsh:R858-859.7 Female Tractography FA(T) fractional anisotropy (threshold) Cognitive Neuroscience lcsh:Computer applications to medicine. Medical informatics Fractional anisotropy medicine nTMS neuronavigated transcranial magnetic stimulation Humans Radiology Nuclear Medicine and imaging ddc:610 KPS Karnofsky performance scale X-sq X-squared (Pearson's chi-square test) FACT fibre assignment by continuous tracking lcsh:Neurology. Diseases of the nervous system Neuronavigation CST M1 primary motor cortex Pyramidal tracts SE standard error business.industry Somatotopic FMRI functional magnetic resonance imaging LT lateral tongue muscle anterior third MFL minimal fibre length MPRAGE magnetization prepared rapid acquisition gradient echo (T1 MR sequence) OR odd's ratio Transcranial magnetic stimulation MEP motor evoked potential PLIC posterior limb of the internal capsule Corticospinal tract FWE family-wise error Neurology (clinical) DTI diffusion tensor imaging business SD standard deviation Diffusion MRI |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical 7, 424-437 (2015). doi:10.1016/j.nicl.2015.01.006 NeuroImage: Clinical, Vol 7, Iss C, Pp 424-437 (2015) |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2015.01.006 |
| Popis: | Imaging of the course of the corticospinal tract (CST) by diffusion tensor imaging (DTI) is useful for function-preserving tumour surgery. The integration of functional localizer data into tracking algorithms offers to establish a direct structure–function relationship in DTI data. However, alterations of MRI signals in and adjacent to brain tumours often lead to spurious tracking results. We here compared the impact of subcortical seed regions placed at different positions and the influences of the somatotopic location of the cortical seed and clinical co-factors on fibre tracking plausibility in brain tumour patients. The CST of 32 patients with intracranial tumours was investigated by means of deterministic DTI and neuronavigated transcranial magnetic stimulation (nTMS). The cortical seeds were defined by the nTMS hot spots of the primary motor area (M1) of the hand, the foot and the tongue representation. The CST originating from the contralesional M1 hand area was mapped as intra-individual reference. As subcortical region of interests (ROI), we used the posterior limb of the internal capsule (PLIC) and/or the anterior inferior pontine region (aiP). The plausibility of the fibre trajectories was assessed by a-priori defined anatomical criteria. The following potential co-factors were analysed: Karnofsky Performance Scale (KPS), resting motor threshold (RMT), T1-CE tumour volume, T2 oedema volume, presence of oedema within the PLIC, the fractional anisotropy threshold (FAT) to elicit a minimum amount of fibres and the minimal fibre length. The results showed a higher proportion of plausible fibre tracts for the aiP-ROI compared to the PLIC-ROI. Low FAT values and the presence of peritumoural oedema within the PLIC led to less plausible fibre tracking results. Most plausible results were obtained when the FAT ranged above a cut-off of 0.105. In addition, there was a strong effect of somatotopic location of the seed ROI; best plausibility was obtained for the contralateral hand CST (100%), followed by the ipsilesional hand CST (>95%), the ipsilesional foot (>85%) and tongue (>75%) CST. In summary, we found that the aiP-ROI yielded better tracking results compared to the IC-ROI when using deterministic CST tractography in brain tumour patients, especially when the M1 hand area was tracked. In case of FAT values lower than 0.10, the result of the respective CST tractography should be interpreted with caution with respect to spurious tracking results. Moreover, the presence of oedema within the internal capsule should be considered a negative predictor for plausible CST tracking. Highlights • Somatotopic CST tractography was done in 32 patients with eloquent brain tumours. • Seeding ROIs were defined by navigated TMS of the M1 hot spot (hand, foot, tongue). • Using the anterior pons as a second ROI yielded more plausible tracts than the PLIC. • Low FAT and oedema of the internal capsule were negative predictors. |
| Databáze: | OpenAIRE |
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